Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers Short Review英文文献资料.docVIP

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Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers Short Review英文文献资料.doc

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Central Dopaminergic System and Its Implications in Stress-Mediated Neurological Disorders and Gastric Ulcers Short Review英文文献资料

HindawiPublishingCorporation AdvancesinPharmacologicalSciences Volume2012,ArticleID182671,11pages doi:10.1155/2012/182671 ReviewArticle CentralDopaminergicSystemand ItsImplicationsinStress-MediatedNeurologicalDisordersand GastricUlcers:ShortReview NailaRasheed andAbdullahAlghasham 1 2 1 2 DepartmentofMedicalBiochemistry,CollegeofMedicine,QassimUniversity,P.O.BOX6655,Buraidah51452,SaudiArabia DepartmentofPharmacologyandTherapeutics,CollegeofMedicine,QassimUniversity,P.O.BOX6655, Buraidah51452,SaudiArabia CorrespondenceshouldbeaddressedtoNailaRasheed,naila1381@ Received6July2012;Revised11August2012;Accepted14August2012 AcademicEditor:MustafaF.Lokhandwala Copyright?2012N.RasheedandA.Alghasham. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Fordecades,ithasbeensuggestedthatdysfunctionofdopaminergicpathwaysandtheirassociatedmodulationsindopaminelevels playamajorroleinthepathogenesisofneurologicaldisorders.Dopaminergicsystemisinvolvedinthestressresponse,andthe neuralmechanismsinvolvedinstressareimportantforcurrentresearch,buttherecentandpastdataonthestressresponseby dopaminergicsystemhavereceivedlittleattention.Therefore,wehavediscussedthesedataonthestressresponseandpropose arolefordopamineincopingwith stress.Inaddition,wehavealsodiscussedgastric stressulcersandtheircorrelationwith dopaminergicsystem.Furthermore,wehavealsohighlightedsomeoftheglucocorticoidsanddopamine-mediatedneurological disorders.Ourliteraturesurveysuggeststhatdopaminergicsystemhasreceivedlittleattentioninbothclinicalandpreclinical researchonstress,butthecurrentresearchonthisissuewillsurelyidentifyabetterunderstandingofstressfuleventsandwillgive betterideasforfurthere?cientantistresstreatments. 1.Introduction (HPA)axisandreleasesglucocorticoids(GCs).Theinterplay between GCs and the dopaminergic system is linked with v