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Canonical Source Reconstruction for MEG英文文献资料
HindawiPublishingCorporation
ComputationalIntelligenceandNeuroscience
Volume2007,ArticleID67613,10pages
doi:10.1155/2007/67613
ResearchArticle
CanonicalSourceReconstructionforMEG
Je′re′mieMattout,1RichardN.Henson,2andKarlJ.Friston3
1
2
INSERMU821,DynamiqueC′er′ebraleetCognition,Lyon,France
MRCCognitionandBrainSciencesUnit,CambridgeCB27EF,UK
3
TheWellcomeTrustCentreforNeuroimaging,UniversityCollege,LondonWC1N3BG,UK
CorrespondenceshouldbeaddressedtoJ′er′emieMattout,jeremiemattout@yahoo.fr
Received11January2007;Revised24April2007;Accepted27May2007
RecommendedbySaiedSanei
Wedescribeasimpleande?cientsolutiontotheproblemofreconstructingelectromagneticsourcesintoacanonicalorstandard
anatomicalspace.Itssimplicityrestsuponincorporatingsubject-speci?canatomyintotheforwardmodelinawaythateschews
theneedforcorticalsurfaceextraction.Theforwardmodelstartswithacanonicalcorticalmesh,de?nedinastandardstereotactic
space.Themeshiswarped,inanonlinearfashion,tomatchthesubject’sanatomy.Thiswarpingistheinverseofthetransforma-
tionderivedfromspatialnormalizationofthesubject’sstructuralMRIimage,usingfullyautomatedproceduresthathavebeen
establishedforotherimagingmodalities.Electromagneticlead?eldsarecomputedusingthewarpedmesh,inconjunctionwith
asphericalheadmodel(whichdoesnotrelyonindividualanatomy).Theensuingforwardmodelisinvertedusinganempirical
Bayesianschemethatwehavedescribedpreviouslyinseveralpublications.Critically,becauseanatomicalinformationentersthe
forwardmodel,thereisnoneedtospatiallynormalizethereconstructedsourceactivity.Inotherwords,eachsource,comprising
themesh,hasapredeterminedanduniqueanatomicalattributionwithinstandardstereotacticspace.Thisenablesthepoolingof
datafrommultiplesubjectsandthereportingofresultsinstereotacticcoordinates.Furthermore,itallowsthegracefulfusionof
fMRIandMEGdatawithinthesameanatomicalframework.
Copyright?2007J′er′emieMattoutetal. This is an open access article distributed under the Creative Commons Attribution
License,whichpermitsunrestricteduse,
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