Brain Miffed by Macrophage Migration Inhibitory Factor英文文献资料.docVIP

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Brain Miffed by Macrophage Migration Inhibitory Factor英文文献资料.doc

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Brain Miffed by Macrophage Migration Inhibitory Factor英文文献资料

HindawiPublishingCorporation InternationalJournalofCellBiology Volume2012,ArticleID139573,11pages doi:10.1155/2012/139573 ReviewArticle BrainMiffedbyMacrophageMigrationInhibitoryFactor NicE.Savaskan, G¨unterFingerle-Rowson, MichaelBuchfelder, andIlkerY.Ey¨upoglu 1 2 1 1 1 2 DepartmentofNeurosurgery,UniversityofErlangen-Nuremberg,Schwabachanlage6,91054Erlangen,Germany ClinicIforInternalMedicine,UniversityHospitalCologne,KerpenerStra?e62,50924Cologne,Germany CorrespondenceshouldbeaddressedtoNicE.Savaskan,Nicolai.savaskan@uk-erlangen.deand IlkerY.Ey¨upoglu,ilker.eyupoglu@uk-erlangen.de Received18May2012;Revised6July2012;Accepted12July2012 AcademicEditor:PierGiorgioMastroberardino Copyright?2012NicE.Savaskanetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Macrophagemigrationinhibitoryfactor(MIF)isacytokinewhichalsoexhibitsenzymaticpropertieslikeoxidoreductaseand tautomerase.MIFplaysapivotalroleininnateandacquiredimmunityaswellasintheneuroendocrineaxis.Sinceitisinvolved in the pathogenesis of acute and chronic in?ammation, neoangiogenesis, and cancer, MIF and its signaling components are consideredsuitabletargetsfortherapeuticinterventioninseveral?eldsofmedicine.Inneurodegenerativeandneurooncological diseases,MIFisahighlyrelevant,butstillahardlyinvestigatedmediator.MIFoperatesviaintracellularprotein-proteininteraction aswellasinCD74/CXCR2/CXCR4receptor-mediatedpathwaystoregulateessentialcellularsystemssuchasredoxbalance,HIF- 1,andp53-mediatedsenescenceandapoptosisaswellasmultiplesignalingpathways.Actingasanendogenousglucocorticoid antagonist, MIF thus represents a relevant resistance gene in brain tumor therapies. Alongside this dual action, a functional homolog-annotated D-dopachrome tautomerase/MIF-2 has been uncovered utilizing the same cell su