Capability of Tissue Stem Cells to Organize into Salivary Rudiments英文文献资料.docVIP

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Capability of Tissue Stem Cells to Organize into Salivary Rudiments英文文献资料.doc

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Capability of Tissue Stem Cells to Organize into Salivary Rudiments英文文献资料

HindawiPublishingCorporation StemCellsInternational Volume2012,ArticleID502136,11pages doi:10.1155/2012/502136 ReviewArticle CapabilityofTissueStemCellstoOrganizeinto SalivaryRudiments KenjiOkumura, MasanoriShinohara, andFumioEndo 1 2 1 1 2 DepartmentofPediatrics,KumamotoUniversitySchoolofMedicine,Honjo1-1-1,Kumamoto860-8556,Japan DepartmentofOralandMaxillofacialSurgery,KumamotoUniversity,Kumamoto,Japan CorrespondenceshouldbeaddressedtoFumioEndo,fendo@kumamoto-u.ac.jp Received8September2011;Accepted5January2012 AcademicEditor:ZevGartner Copyright?2012KenjiOkumuraetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Branchingmorphogenesis(BrM),anessentialstepforsalivaryglanddevelopment,requiresepithelial-mesenchymalinteractions. BrMisimpairedwhenthesurroundingmesenchymeisdetachedfromthesalivaryepitheliumduringthepseudoglandularstage. ItisbelievedthatthesalivarymesenchymeisindispensableforBrM,however,anextracellularmatrixgelwithexogenousEGFcan beusedasasubstituteforthemesenchymeduringBrMinthedevelopingsalivaryepithelium.Stem/progenitorcellsisolatedfrom salivaryglandsinhumansandrodentscanbeclassi?edasmesenchymalstemcell-like,bone-marrow-derived,ductcell-like,and embryonicepithelium-likecells.Salivary-gland-derivedprogenitor(SGP)cellsisolatedfromduct-ligatedrats,mice,andswine submandibularglandssharesimilarcharacteristics,includingintracellularlamininandα6β1-integrinexpression,similartothe embryonicsalivaryepitheliaduringthepseudoglandularstage.Progenitorcellsalsoisolatedfromhumansalivaryglands(human SGPcells)havingthesamecharacteristicsdi?erentiateintohepatocyte-likecellswhentransplantedintotheliver.Similartothe dissociatedembryonicsalivaryepithelium,humanSGPcellsaggregatetoself-organizeintobranchingorgan-likestructureson MatrigelplusexogenousEGF.Theseresultssuggestthepossibilit