Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimers Disease Investigation of a Possible Mechanism of Action英文文献资料.docVIP

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Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimers Disease Investigation of a Possible Mechanism of Action英文文献资料.doc

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Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimers Disease Investigation of a Possible Mechanism of Action英文文献资料

HindawiPublishingCorporation InternationalJournalofAlzheimer’sDisease Volume2012,ArticleID381974,9pages doi:10.1155/2012/381974 ResearchArticle CentellaasiaticaExtractImprovesBehavioralDe?cits inaMouseModelofAlzheimer’sDisease:Investigationof aPossibleMechanismofAction AmalaSoumyanath, Yong-PingZhong, EdwardHenson, TeriWadsworth, 1 1 1 1 JamesBishop, BruceG.Gold, 1andJosephF.Quinn 1,2 1 1 2 DepartmentofNeurology,OregonHealthScienceUniversity,Portland,OR97239,USA DepartmentofNeurology,PortlandVAMedicalCenter,Portland,OR97239,USA CorrespondenceshouldbeaddressedtoAmalaSoumyanath,soumyana@ Received1August2011;Accepted26October2011 AcademicEditor:AbduAdem Copyright?2012AmalaSoumyanathetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Centellaasiatica(CA),commonlynamedgotukola,isanAyurvedicherbusedtoenhancememoryandnervefunction.Toinves- tigatethepotentialuseofCAinAlzheimer’sdisease(AD),weexaminedthee?ectsofawaterextractofCA(GKW)intheTg2576 mouse,amurinemodelofADwithhighβ-amyloidburden.OrallyadministeredGKWattenuatedβ-amyloid-associatedbehavioral abnormalitiesinthesemice.Invitro,GKWprotectedSH-SY5YcellsandMC65humanneuroblastomacellsfromtoxicityinduced byexogenouslyaddedandendogenouslygeneratedβ-amyloid,respectively.GKWpreventedintracellularβ-amyloidaggregatefor- mationinMC65cells.GKWdidnotshowanticholinesteraseactivityorprotectneuronsfromoxidativedamageandglutamatetoxi- city,mechanismsofcurrentADtherapies.GKWisrichinphenoliccompoundsanddoesnotcontainasiaticacid,aknownCA neuroprotectivetriterpene.CAthuso?ersauniquetherapeuticmechanismandnovelactivecompoundsofpotentialrelevanceto thetreatmentofAD. 1.Introduction enhancementinlearninge?ciencyandspatialmemorywith no e?ects on locomotor function [6]. Direct neurotropic e?ectsofCAhavealsobeenreported.CAaqueousextract causedsigni?canti