Cellular Therapy for Repair of Cardiac Damage after Acute Myocardial Infarction英文文献资料.docVIP
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Cellular Therapy for Repair of Cardiac Damage after Acute Myocardial Infarction英文文献资料
HindawiPublishingCorporation
InternationalJournalofCellBiology
Volume2009,ArticleID906507,11pages
doi:10.1155/2009/906507
ReviewArticle
CellularTherapyforRepairofCardiacDamageafter
AcuteMyocardialInfarction
GaryP.Brooke,
MatthewM.Cook,1,2KatarinaKollar,1 1andKerryAtkinson 1,2
1
2
AdultStemCellLaboratory,MaterMedicalResearchInstitute,SouthBrisbane,QLD4101,Australia
SchoolofMedicine,UniversityofQueensland,StLucia,QLD4072,Australia
CorrespondenceshouldbeaddressedtoKerryAtkinson,kerry.atkinson@.au
Received11December2008;Accepted3February2009
RecommendedbyGaryS.Stein
Cardiovasculardiseases,particularlyacutemyocardialinfarction,aretheleadingcausesofdeathworldwide.Importantadvances
havebeenmadeinthesecondarytreatmentforcardiovasculardiseasessuchashearttransplantationandmedicalandsurgical
therapies.Althoughthesetherapiesalleviatesymptoms,andmayevenimprovesurvival,nonecanreversethediseaseprocessand
directlyrepairthelastingdamage.Thus,thecureofcardiovasculardiseasesremainsamajorunmetmedicalneed.Recently,cellular
therapyhasbeenproposedasacandidatetreatmentforthis.Manystemandprogenitorcellpopulationshaveeachbeensuggested
asapotentialbasisforsuchtherapy.Thisreviewassessessomeofthemorenotableexogenousadultcellcandidatesandprovides
insightsintothemechanismsbywhichtheymaymediateimprovementincardiacfunctionfollowingacutemyocardialinfarction.
Researchintothecellulartherapy?eldisofgreatimportanceforthefurtherplanningofclinicaltrialsforcardiaccellularmyoplasty.
Copyright?2009MatthewM.Cooketal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
1.Introduction
artery bypass graft surgery, left ventricular assist devices
andbiventricularpacinghavemadeasigni?cantimpacton
thecardiovasculardiseaseburden.Hearttransplantationis
also well established, but the need for long-term immune
suppressionandthechronicdonororganshortagessuggest
thatit
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