Cellular viability and nitric oxide (NO) production by J774 macrophages in the presence of orthodontic archwires英文文献资料.docVIP

J. Biomedical Science and Engineering, 2012, 5, 255-262 JBiSE /10.4236/jbise.2012.55032 Published Online May 2012 (http://www.SciRP.org/journal/jbise/) Cellular viability and nitric oxide (NO) production by J774 macrophages in the presence of orthodontic archwires Carlos E. P. Toledo , Maria A. Souza , Marcelo R. Fraga , Luiz C. Ribeiro , 1* 2 3 4 3 Ana P. Ferreira 5 , Robert W. F. Vitral 1 2 3 4 5 Juiz de Fora Federal University, Juiz de Fora, Brazil Institute of Biomedical Sciences, Uberlandia Federal University, Uberlandia, Brazil Department of Orthodontics and Pediatrics, Juiz de Fora Federal University, Juiz de Fora, Brazil Department of Statistic, Juiz de Fora Federal University, Juiz de Fora, Brazil Department of Parasitology, Microbiology and Immunology, Juiz de Fora Federal University, Juiz de Fora, Brazil Email: carlostoledo1@ * Received 17 January 2012; revised 12 February 2011; accepted 21 March 2012 ABSTRACT bility, i.e. the lack of the coexistence of manufactured materials with body tissues and fluids, which should re- main in the organism for varied periods of time without harming the soft tissues. Very few dentistry materials, maybe even none, are totally inert from the biological point of view because they have a variety of components with toxic and irritative potentiality [1,2]. Biocompati- bility is characterized by the capacity of the materials to not cause toxic, irritative, inflammatory, allergic, muta- genic or carcinogenic effects in tissues [3-6]. The development of biocompatible materials has been one of the greatest challenges in the health field. One of the main parameters for the evaluation of biological re- sponse and damage or cell death potential are the cyto- toxicity tests, which are the first trial tests used for al- most all the materials [7]