Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products英文文献资料.docVIP

HindawiPublishingCorporation JournalofOncology Volume2010,ArticleID739852,8pages doi:10.1155/2010/739852 ResearchArticle CancerMalignancyIsEnhancedbyGlyceraldehyde-Derived AdvancedGlycationEnd-Products Jun-IchiTakino, Sho-IchiYamagishi, andMasayoshiTakeuchi 1 2 1 1 DepartmentofLifePharmacy,FacultyofPharmaceuticalSciences,HokurikuUniversity,Ho-3Kanagawa-machi, Kanazawa920-1181,Japan 2 DepartmentofPathophysiologyandTherapeuticsofDiabeticVascularComplications,KurumeUniversitySchoolofMedicine, 67Asahimachi,Kurume830-0011,Japan CorrespondenceshouldbeaddressedtoMasayoshiTakeuchi,m-takeuchi@hokuriku-u.ac.jp Received2November2009;Revised24April2010;Accepted9May2010 AcademicEditor:JamesL.Mulshine Copyright?2010Jun-IchiTakinoetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEsdidnot.However,thee?ectsofGlycer-AGEsonothercancercellsremainpoorlyunderstood,andthemolecularmechanisms behind the above-mentioned e?ect have not been clari?ed. The present paper aimed to examine the e?ect of Glycer-AGEs onculturedlungcancerA549cells.RAGEwasexpressedinA549cells.Glycer-AGEssigni?cantlyattenuatedcellproliferation. Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity. We demonstrated that Glycer-AGEs enhanced the migration and invasion of A549 cells rather than their proliferation.TheseresultssuggestthatGlycer-AGEsplayacriticalroleinthemalignancyofcancerratherthanitsproliferation andarepotentialtargetsfortherapeuticintervention. 1.Introduction reportshavesuggestedth