Dendritic Spines and Development Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajals Histological Slides and Drawings 外文参考文献.docVIP
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Dendritic Spines and Development Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajals Histological Slides and Drawings 外文参考文献
HindawiPublishingCorporation
NeuralPlasticity
Volume2010,ArticleID769207,29pages
doi:10.1155/2010/769207
ReviewArticle
DendriticSpinesandDevelopment:Towardsa
UnifyingModelofSpinogenesis—APresentDayReviewofCajal’s
HistologicalSlidesandDrawings
PabloGarc′?a-Lo′pez,VirginiaGarc′?a-Mar′?n,andMiguelFreire
DepartmentofMolecular,CellularandDevelopmentalNeurobiology,InstitutoCajal,CSIC,AvenidaDoctorArce37,
28002Madrid,Spain
CorrespondenceshouldbeaddressedtoMiguelFreire,mfreire2@
Received23September2010;Accepted14November2010
AcademicEditor:MichaelStewart
Copyright?2010PabloGarc′?a-Lo′pezetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Dendriticspinesreceivethemajorityofexcitatoryconnectionsinthecentralnervoussystem,and,thus,theyarekeystructures
intheregulation ofneuralactivity. Hence, thecellularandmolecularmechanismsunderlyingtheirgenerationandplasticity,
bothduringdevelopmentandinadulthood,areamatteroffundamentalandpracticalinterest.Indeed,abetterunderstandingof
thesemechanismsshouldprovidecluestothedevelopmentofnovelclinicaltherapies.Here,wepresentoriginalresultsobtained
from high-quality images of Cajal’s histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained
usingextended focus imaging, three-dimensional reconstruction, andrendering. Based onthe dataavailableinthe literature
regardingtheformationofdendriticspinesduringdevelopmentandourresults,weproposeaunifyingmodelfordendriticspine
development.
1.Introduction
establishedatdendriticspines[9,10],eventhoughexcitatory
connectionscanalsoendondendriticshafts[11,12].Many
authorshavecontributedtotheknowledgeofthedendritic
spines using light microscopy, electron microscopy and
three-dimensional (3D)reconstructions onserial ultrathin
sections;studyingplasticchanges,distribution,pathological
changes,andsoforth,(see[13]).
Dendriticspineswere?rstdiscover
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