Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus 英文参考文献.docVIP

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Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus 英文参考文献.doc

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Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus 英文参考文献

o PL SMEDICINE ElevatedSerumLevelsofInterferon-Regulated ChemokinesAreBiomarkersforActiveHuman SystemicLupusErythematosus Jason W. Bauer1,Emily C.Baechler1,Michelle Petri2,Franak M.Batliwalla3,Dianna Crawford1,Ward A.Ortmann1, Karl J.Espe1,Wentian Li3,Dhavalkumar D.Patel4,Peter K.Gregersen3,Timothy W. Behrens1*¤ 1CenterforImmunology,UniversityofMinnesotaMedicalSchool,Minneapolis,Minnesota,UnitedStatesofAmerica,2DepartmentofMedicine,JohnsHopkinsUniversity SchoolofMedicine,Baltimore,Maryland,UnitedStatesofAmerica,3NorthShoreLongIslandJewishResearchInstitute,Manhasset,NewYork,UnitedStatesofAmerica, 4ThurstonArthritisResearchCenter,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolina,UnitedStatesofAmerica Funding:Seesectionatendof manuscript. ABSTRACT CompetingInterests:Seesectionat endofmanuscript. Background Systemiclupuserythematosus(SLE)isaserioussystemicautoimmunedisorderthataffects multipleorgansystemsandischaracterizedbyunpredictableflaresofdisease.Recentevidence indicatesarolefortypeIinterferon(IFN)inSLEpathogenesis;however,thedownstreameffects ofIFNpathwayactivationarenotwellunderstood.HerewetestthehypothesisthattypeIIFN- regulatedproteinsarepresentintheserumofSLEpatientsandcorrelatewithdiseaseactivity. AcademicEditor:Richard Sontheimer,UniversityofIowa, UnitedStatesofAmerica Citation:BauerJW,BaechlerEC, PetriM,BatliwallaFM,CrawfordD,et al.(2006)Elevatedserumlevelsof interferon-regulatedchemokinesare biomarkersforactivehuman systemiclupuserythematosus.PLoS Med3(12):e491.doi:10.1371/journal. pmed.0030491 MethodsandFindings We performed a comprehensive survey of the serologic proteome in human SLE and identified dysregulated levels of 30 cytokines, chemokines, growth factors, and soluble receptors. Particularly striking was the highly coordinated up-regulation of 12 inflammatory and/or homeostatic chemokines, molecules that direct the movement of leukocytes in the body. Most of the identified chemokines were inducible by type I IFN, and their lev