Encoding of Spatio-Temporal Input Characteristics by a CA1 Pyramidal Neuron Model 英文参考文献.docVIP
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Encoding of Spatio-Temporal Input Characteristics by a CA1 Pyramidal Neuron Model 英文参考文献
EncodingofSpatio-TemporalInputCharacteristicsbya
CA1PyramidalNeuronModel
EleftheriaKyriakiPissadaki1,2¤*,KyriakiSidiropoulou2,MartinReczko3,PanayiotaPoirazi2*
1Department of Biology, University of Crete, Heraklion, Crete, Greece, 2Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology,
Heraklion,Crete,Greece,3InstituteofMolecularOncology,AlexanderFlemingBiomedicalSciencesResearchCenter,Athens,Greece
Abstract
The in vivo activity of CA1 pyramidal neurons alternates between regular spiking and bursting, but how these changes
affectinformationprocessingremainsunclear.UsingadetailedCA1pyramidalneuronmodel,weinvestigatehowtiming
andspatialarrangementvariationsinsynapticinputstothedistalandproximaldendriticlayersinfluencetheinformation
contentofmodelresponses.Wefindthatthetemporaldelaybetweenactivationofthetwolayersactsasaswitchbetween
excitability modes: short delays induce bursting while long delays decrease firing. For long delays, the average firing
frequencyofthemodelresponsediscriminatesspatiallyclusteredfromdiffusedinputstothedistaldendritictree.Forshort
delays, the onset latency and inter-spike-interval succession of model responses can accurately classify input signals as
temporallycloseordistantandspatiallyclusteredordiffusedacrossdifferentstimulationprotocols.Thesefindingssuggest
thataCA1pyramidalneuronmaybecapableofencodingandtransmittingpresynapticspatiotemporalinformationabout
theactivityoftheentorhinalcortex-hippocampalnetworktohigherbrainregionsviatheselectiveuseofeitheratemporal
oraratecode.
Citation:PissadakiEK,SidiropoulouK,ReczkoM,PoiraziP(2010)EncodingofSpatio-TemporalInputCharacteristicsbyaCA1PyramidalNeuronModel.PLoS
ComputBiol6(12):e1001038.doi:10.1371/journal.pcbi.1001038
Editor:LyleJ.Graham,Universite′ ParisDescartes,CentreNationaldelaRechercheScientifique,France
ReceivedMarch24,2010;AcceptedNovember19,2010;PublishedDecember16,2010
Copyright: ? 2010 Pissadaki et al. This is an open-access article distributed
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