Enhancing Adverse Drug Event Detection in Electronic Health Records Using Molecular Structure Similarity Application to Pancreatitis 英文参考文献.docVIP

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Enhancing Adverse Drug Event Detection in Electronic Health Records Using Molecular Structure Similarity Application to Pancreatitis 英文参考文献.doc

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Enhancing Adverse Drug Event Detection in Electronic Health Records Using Molecular Structure Similarity Application to Pancreatitis 英文参考文献

EnhancingAdverseDrugEventDetectioninElectronic HealthRecordsUsingMolecularStructureSimilarity: ApplicationtoPancreatitis SantiagoVilar1,2*,RaveHarpaz1,LourdesSantana2,EugenioUriarte2,CarolFriedman1 1DepartmentofBiomedicalInformatics,ColumbiaUniversityMedicalCenter,NewYork,NewYork,UnitedStatesofAmerica,2DepartmentofOrganicChemistry,Faculty ofPharmacy,UniversityofSantiagodeCompostela,SantiagodeCompostela,Spain Abstract Background:Adversedrugevents(ADEs)detectionandassessmentisatthecenterofpharmacovigilance.Dataminingof systems,suchasFDA’sAdverseEventReportingSystem(AERS)andmorerecently,ElectronicHealthRecords(EHRs),canaid in the automatic detection and analysis of ADEs. Although different data mining approaches have been shown to be valuable,itisstillcrucialtoimprovethequalityofthegeneratedsignals. Objective:Toleveragestructuralsimilaritybydevelopingmolecularfingerprint-basedmodels(MFBMs)tostrengthenADE signalsgeneratedfromEHRdata. Methods:Areferencestandardofdrugsknowntobecausallyassociatedwiththeadverseeventpancreatitiswasusedto create a MFBM. Electronic Health Records (EHRs) from the New York Presbyterian Hospital were mined to generate structured data. Disproportionality Analysis (DPA) was applied to the data, and 278 possible signals related to the ADE pancreatitisweredetected.CandidatedrugsassociatedwiththesesignalswerethenassessedusingtheMFBMtofindthe mostpromisingcandidatesbasedonstructuralsimilarity. Results:TheuseofMFBMasameanstostrengthenorprioritizesignalsgeneratedfromtheEHRsignificantlyimprovedthe detectionaccuracyofADEsrelatedtopancreatitis.MFBMalsohighlightstheetiologyoftheADEbyidentifyingstructurally similardrugs,whichcouldfollowasimilarmechanismofaction. Conclusion:ThemethodproposedinthispaperprovidesevidenceofbeingapromisingadjuncttoexistingautomatedADE detectionandanalysisapproaches. Citation: Vilar S, Harpaz R, Santana L, Uriarte E, Friedman C (2012) Enhancing Adverse Drug Event Detection in Electronic Health Records Using Molecular StructureSimi