Emergence of Tuning to Natural Stimulus Statistics along the Central Auditory Pathway 英文参考文献.docVIP
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Emergence of Tuning to Natural Stimulus Statistics along the Central Auditory Pathway 英文参考文献
EmergenceofTuningtoNaturalStimulusStatisticsalong
theCentralAuditoryPathway
JoseA.Garcia-Lazaro,BashirAhmed,JanW.H.Schnupp*
DepartmentofPhysiology,AnatomyandGenetics,SherringtonBuilding,ParksRoad,Oxford,UnitedKingdom
Abstract
Wehavepreviouslyshownthatneuronsinprimaryauditorycortex(A1)ofanaesthetized(ketamine/medetomidine)ferrets
respond more strongly and reliably to dynamic stimuli whose statistics follow ‘‘natural’’ 1/f dynamics than to stimuli
exhibitingpitchandamplitudemodulationsthatarefaster(1/f 0.5)orslower(1/f 2)than1/f.Toinvestigatewherealongthe
centralauditorypathwaythis1/f-modulationtuningarises,wehavenowcharacterizedresponsesofneuronsinthecentral
nucleusoftheinferiorcolliculus(ICC)andtheventraldivisionofthemediategeniculatenucleusofthethalamus(MGV)to1/
fcdistributedstimuliwithcvaryingbetween0.5and2.8.Wefoundthat,whilethegreatmajorityofneuronsrecordedfrom
theICCshowedastrongpreferenceforthemostrapidlyvarying(1/f 0.5distributed)stimuli,responsesfromMGVneurons
did not exhibit marked or systematic preferences for any particular c exponent. Only in A1 did a majority of neurons
respondwithhigherfiringratestostimuliinwhichctakesvaluesnear1.Theseresultsindicatethat1/ftuningemergesat
forebrainlevelsoftheascendingauditorypathway.
Citation:Garcia-LazaroJA,AhmedB,SchnuppJWH(2011)EmergenceofTuningtoNaturalStimulusStatisticsalongtheCentralAuditoryPathway.PLoSONE6(8):
e22584.doi:10.1371/journal.pone.0022584
Editor:LiI.Zhang,UniversityofSouthernCalifornia,UnitedStatesofAmerica
ReceivedMay6,2011;AcceptedJune24,2011;PublishedAugust5,2011
Copyright:?2011Garcia-Lazaroetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisresearchwassupportedbyBBSRC(BiotechnologyandBiologicalSciencesResearchCouncil)grantNbrBB/D009758/1andEPSRC(Engineeringand
Physical Sciences Research Council) grantNbrEP/C010841/1
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