Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier 英文参考文献.docVIP

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Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier 英文参考文献.doc

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Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier 英文参考文献

EpidermalTransglutaminase(TGase3)IsRequiredfor ProperHairDevelopment,butNottheFormationofthe EpidermalBarrier SusanJohn1,2*,LarsThiebach1,ChristianFrie1,SharadaMokkapati3,ManuelaBechtel3,RoswithaNischt3, SallyRosser-Davies4,MatsPaulsson1,5,NeilSmyth1,4 1CenterforBiochemistry,UniversityofCologne,Cologne,NorthRhine-Westphalia,Germany,2CenterforMolecularMedicine(CMMC),UniversityofCologne,Cologne, NorthRhine-Westphalia,Germany,3DepartmentofDermatology,UniversityofCologne,Cologne,NorthRhine-Westphalia,Germany,4TheSchoolofBiologicalSciences, UniversityofSouthampton,Southampton,UnitedKingdom,5CologneExcellenceClusteronCellularStressResponsesinAging-associatedDiseases(CECAD),Cologne, NorthRhine-Westphalia,Germany Abstract Transglutaminases(TGase),afamilyofcross-linkingenzymespresentinmostcelltypes,areimportantineventsasdiverseas cell-signalingandmatrixstabilization.Transglutaminase1iscrucialindevelopingtheepidermalbarrier,howevertheskin alsocontainsotherfamilymembers,inparticularTGase3.Thisisoformishighlyexpressedinthecornifiedlayer,whereitis believedtostabilizetheepidermisanditsreductionisimplicatedinpsoriasis.TounderstandtheimportanceofTGase3in vivowehavegeneratedandanalyzedmicelackingthisprotein.Surprisingly,theseanimalsdisplaynoobviousdefectinskin development,noovertchangesinbarrierfunctionorabilitytohealwounds.Incontrast,hairlackingTGase3isthinner,has majoralterationsinthecuticlecellsandhairproteincross-linkingismarkedlydecreased.Apparently,whileTGase3isof uniquefunctionalimportanceinhair,intheepidermislossofTGase3canbecompensatedforbyotherfamilymembers. Citation:JohnS,ThiebachL,FrieC,MokkapatiS,BechtelM,etal.(2012)EpidermalTransglutaminase(TGase3)IsRequiredforProperHairDevelopment,butNot theFormationoftheEpidermalBarrier.PLoSONE7(4):e34252.doi:10.1371/journal.pone.0034252 Editor:JohannaM.Brandner,UniversityHospitalHamburg-Eppendorf,Germany ReceivedDecember2,2011;AcceptedFebruary24,2012;PublishedApril4,2012 Copyright: ? 2012 John et al. This is an open-access article