Extraction and Characterization of Essential Discharge Patterns from Multisite Recordings of Spiking Ongoing Activity 英文参考文献.docVIP

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Extraction and Characterization of Essential Discharge Patterns from Multisite Recordings of Spiking Ongoing Activity 英文参考文献.doc

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Extraction and Characterization of Essential Discharge Patterns from Multisite Recordings of Spiking Ongoing Activity 英文参考文献

ExtractionandCharacterizationofEssentialDischarge PatternsfromMultisiteRecordingsofSpikingOngoing Activity RiccardoStorchi1,2*,GabrieleE.M.Biella3,DiegoLiberati4,GiuseppeBaselli5 1DepartmentofBiomedicalSciences,UniversityofModena,Modena,Italy,2InstituteofMolecularBioimagingandPhysiology,Milan,Italy,3NationalResearchCouncil, InstituteofMolecularBioimagingandPhysiology,Milan,Italy,4DepartmentofElectronicandInformation,NationalResearchCouncil,PolitechnicSchoolofMilan,Milan, Italy,5DepartmentofBiomedicalEngineering,PolitechnicSchoolofMilan,Milan,Italy Abstract Background: Neural activation patterns proceed often by schemes or motifs distributed across the involved cortical networks.Asneuronsarecorrelated,theestimateofallpossibledependenciesquicklygoesoutofcontrol.Thecomplex nestingofdifferentoscillationfrequenciesandtheirhighnon-stationarietyfurtherhamperanyquantitativeevaluationof spikingnetworkactivities.Theproblemisexacerbatedbytheintrinsicvariabilityofneuralpatterns. Methodology/Principal Findings: Our technique introduces two important novelties and enables to insulate essential patternsonlargersetsofspikingneuronsandbrainactivityregimes.First,thesamplingprocedureoverNunitsisbasedon afixedspikenumberkinordertodetectN-dimensionalarrays(k-sequences),whosesumoveralldimensionisk.Thenk- sequences variability is greatly reduced by a hierarchical separative clustering, that assigns large amounts of distinct k- sequencestofewclasses.Iterativeseparationsarestoppedwhenthedimensionofeachclustercomestobesmallerthana certainthreshold.Asthresholdtuningcriticallyimpactsonthenumberofclassesextracted,wedevelopedaneffectivecost criteriontoselecttheshortestpossibledescriptionofourdataset.Finallywedescribedthreeindexes(C,S,R)toevaluatethe averagepatterncomplexity,thestructureofessentialclassesandtheirstabilityintime. Conclusions/Significance:Wevalidatedthisalgorithmwithfourkindsofsurrogatedactivity,rangingfromrandomtovery regularpatterned.Thenwecharacterizedaselectionofongoingactivity