Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments A Systematic Review 英文参考文献.docVIP

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Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments A Systematic Review 英文参考文献.doc

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Methods of Blinding in Reports of Randomized Controlled Trials Assessing Pharmacologic Treatments A Systematic Review 英文参考文献

o PL SMEDICINE MethodsofBlindinginReportsofRandomized ControlledTrialsAssessingPharmacologic Treatments:ASystematicReview Isabelle Boutron1,2,3*,Candice Estellat1,2,3,Lydia Guittet1,2,3,Agnes Dechartres1,2,3,David L.Sackett4, Asbj?rnHro′bjartsson5,Philippe Ravaud1,2,3 1 INSERM U738, Paris, France, 2 Universite′ Paris 7, UFR de Me′decine, Paris, France, 3 AP-HP, Ho?pital Bichat, De′partement d’Epide′miologie, Biostatistique et Recherche Clinique,Paris,France,4TroutResearchandEducationCentreatIrishLake,Markdale,Ontario,Canada,5NordicCochraneCentre,Rigshospitalet,Copenhagen,Denmark Funding:Theauthorsreceivedno specificfundingforthisstudy. ABSTRACT CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. Background Blinding is a cornerstone of therapeutic evaluation because lack of blinding can bias treatmenteffectestimates.Aninventoryoftheblindingmethodswouldhelptrialistsconduct high-quality clinical trials and readers appraise the quality of results of published trials. We aimed to systematically classify and describe methods to establish and maintain blinding of patients and health care providers and methods to obtain blinding of outcome assessors in randomizedcontrolledtrialsofpharmacologictreatments. AcademicEditor:PatrickVallance, GlaxoSmithKline,UnitedKingdom Citation:BoutronI,EstellatC, GuittetL,DechartresA,SackettDL, etal.(2006)Methodsofblindingin reportsofrandomizedcontrolled trialsassessingpharmacologic treatments:Asystematicreview. PLoSMed3(10):e425.DOI:10.1371/ journal.pmed.0030425 MethodsandFindings We undertook a systematic review of all reports of randomized controlled trials assessing pharmacologictreatmentswithblindingpublishedin2004inhighimpact-factorjournalsfrom MedlineandtheCochraneMethodologyRegister.Weusedastandardizeddatacollectionform toextractdata.Theblindingmethodswereclassifiedaccordingtowhethertheyprimarily(1) establishedblindingofpatientsorhealthcareproviders,(2)maintainedtheblindingofpatients or health care providers,