Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies 英文参考文献.docVIP

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Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies 英文参考文献.doc

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Neural Stem Cells as a Novel Platform for Tumor-Specific Delivery of Therapeutic Antibodies 英文参考文献

NeuralStemCellsasaNovelPlatformforTumor-Specific DeliveryofTherapeuticAntibodies RichardT.Frank1*,MarissaEdmiston1,StephenE.Kendall2,JosephNajbauer1,Chia-WeiCheung3, ThewodrosKassa3,MarianneZ.Metz1,SeungU.Kim6,7,CarlottaA.Glackin2,AnnaM.Wu5,PaulJ. Yazaki3,KarenS.Aboody1,4* 1DivisionsofHematologyandHematopoieticCellTransplantation,CityofHopeNationalMedicalCenterandBeckmanResearchInstitute,Duarte,California,UnitedStates ofAmerica, 2Department ofMolecular Medicine,City ofHope NationalMedical Center and Beckman Research Institute, Duarte, California, United States ofAmerica, 3DepartmentofCancerImmunotherapyandTumorImmunology,CityofHopeNationalMedicalCenterandBeckmanResearchInstitute,Duarte,California,UnitedStates of America, 4Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, United States of America, 5DepartmentofMolecularandMedicalPharmacology,DavidGeffenSchoolofMedicine,UniversityofCaliforniaLosAngeles,LosAngeles,California,UnitedStatesof America,6DivisionofNeurology,DepartmentofMedicine,UBCHospital,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada,7InstituteforRegenerative Medicine,GachonUniversityGilHospital,Inchon,Korea Abstract Background: Recombinant monoclonal antibodies have emerged as important tools for cancer therapy. Despite the promise shown by antibody-based therapies, the large molecular size of antibodies limits their ability to efficiently penetratesolidtumorsandprecludesefficientcrossingoftheblood-brain-barrier intothecentralnervoussystem (CNS). Consequently,poorlyvascularizedsolidtumorsandCNSmetastasescannotbeeffectivelytreatedbyintravenously-injected antibodies. The inherent tumor-tropic properties of human neural stem cells (NSCs) can potentially be harnessed to overcome these obstacles and significantly improve cancer immunotherapy. Intravenously-delivered NSCs preferentially migratetoprimary andmetastatic tumorsiteswithinandoutsidetheCNS.Therefore,wehypothes