Organization of Cellular Receptors into a Nanoscale Junction during HIV-1 Adhesion 英文参考文献.docVIP

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Organization of Cellular Receptors into a Nanoscale Junction during HIV-1 Adhesion 英文参考文献.doc

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Organization of Cellular Receptors into a Nanoscale Junction during HIV-1 Adhesion 英文参考文献

OrganizationofCellularReceptorsintoaNanoscale JunctionduringHIV-1Adhesion TerrenceM.Dobrowsky1,BrianR.Daniels1,RobertF.Siliciano2,SeanX.Sun1,3,4,DenisWirtz1,4 * 1Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America, 2Howard Hughes Medical InstituteandDepartmentofMedicine,TheJohnsHopkinsSchoolofMedicine,Baltimore,Maryland,UnitedStatesofAmerica,3DepartmentofMechanicalEngineering, The Johns Hopkins University, Baltimore, Maryland, United States of America, 4Johns Hopkins Physical Sciences in Oncology Center, The Johns Hopkins University, Baltimore,Maryland,UnitedStatesofAmerica Abstract The fusion of the human immunodeficiency virus type 1 (HIV-1) with its host cell is the target for new antiretroviral therapies.Viralparticlesinteractwiththeflexibleplasmamembraneviaviralsurfaceproteingp120whichbindsitsprimary cellular receptor CD4 and subsequently the coreceptor CCR5. However, whether and how these receptors become organizedattheadhesivejunctionbetweencellandvirionareunknown.Here,stochasticmodelingpredictsthat,regarding binding to gp120, cellular receptors CD4 and CCR5 form an organized, ring-like, nanoscale structure beneath the virion, whichlocallydeformstheplasmamembrane.Thisorganizedadhesivejunctionbetweencellandvirion,whichwenamethe viral junction, is reminiscent of the well-characterized immunological synapse, albeit at much smaller length scales. The formation of an organized viral junction under multiple physiopathologically relevant conditions may represent a novel intermediatestepinproductiveinfection. Citation: Dobrowsky TM, Daniels BR, Siliciano RF, Sun SX, Wirtz D (2010) Organization of Cellular Receptors into a Nanoscale Junction during HIV-1 Adhesion.PLoSComputBiol6(7):e1000855.doi:10.1371/journal.pcbi.1000855 Editor:RustomAntia,EmoryUniversity,UnitedStatesofAmerica ReceivedNovember20,2009;AcceptedJune4,2010;PublishedJuly15,2010 Copyright: ?2010Dobrowskyetal.Thisisanopen-access