Outcome of postoperative critically ill patients with heparin-induced thrombocytopenia an observational retrospective case-control study 英文参考文献.docVIP

Available online /content/10/6/R161 Research Open Access Vol 10 No 6 Outcome of postoperative critically ill patients with heparin-induced thrombocytopenia: an observational retrospective case-control study Elise M Gettings1, Kathryn A Brush2, Elizabeth M Van Cott3 and William E Hurford1 1Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA 2Department of Nursing, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA 3Department of Clinical Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA Corresponding author: William E Hurford, William.hurford@ Received: 31 Aug 2006 Revisions requested: 10 Oct 2006 Revisions received: 7 Nov 2006 Accepted: 16 Nov 2006 Published: 16 Nov 2006 Critical Care 2006, 10:R161 (doi:10.1186/cc5100) This article is online at: /content/10/6/R161 ? 2006 Gettings et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Heparin-induced thrombocytopenia (HIT) is Nineteen patients (0.9% of admissions; 9% of tested described as a decrease in platelet count associated with heparin administration and is an immune-mediated adverse drug reaction that can cause both arterial and venous thromboses. It can be a life-threatening complication of heparin exposure. Little data concerning incidence, predisposing factors, or outcome in critically ill surgical patients are available. individuals) had positive tests. HIT-antibody-positive patients, compared with 19 matched controls, had an increased risk of death or major thrombotic complications (37% versus 10%; P 0.05) and prolonged length of intensive care unit (ICU) stay (20 days versus 10 days; P 0.05).