Prognostic Significance of New Immunohistochemical Markers in Refractory Classical Hodgkin Lymphoma A Study of 59 Cases 英文参考文献.docVIP

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Prognostic Significance of New Immunohistochemical Markers in Refractory Classical Hodgkin Lymphoma A Study of 59 Cases 英文参考文献.doc

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Prognostic Significance of New Immunohistochemical Markers in Refractory Classical Hodgkin Lymphoma A Study of 59 Cases 英文参考文献

PrognosticSignificanceofNewImmunohistochemical MarkersinRefractoryClassicalHodgkinLymphoma:A Studyof59Cases DanielleCanioni1.*,Be′ne′dicteDeau-Fischer2.,PierreTaupin3,VincentRibrag4,RichardDelarue2, JacquesBosq5,Marie-The′re`seRubio2,DamienRoux2,ViorelVasiliu1,BrunoVaret2,NicoleBrousse1, OlivierHermine2 1Department of Pathology, Necker Hospital, Assistance Publique-Ho?pitaux de Paris, University Paris-Descartes, Faculte′ de Me′decine, Paris, France, 2Department of Hematology,NeckerHospital,AssistancePublique-Ho?pitauxdeParis,UniversityParis-Descartes,Faculte′ deMe′decine,Paris,France,3DepartmentofBiostatistics,Necker Hospital,AssistancePublique-Ho?pitauxdeParis,UniversityParis-Descartes,Faculte′ deMe′decine, Paris,France,4DepartmentofHematology,GustaveRoussyInstitute, Villejuif,France,5DepartmentofPathology,GustaveRoussyInstitute,Villejuif,France Abstract AlthoughmostclassicalHodgkinlymphomapatientsarecured,asignificantminorityfailafterprimarytherapyandmaydie asresultoftheirdisease.Todate,thereisnoconsensusonbiologicalmarkersthataddvaluetousualparameters(which comprise the International Prognostic Score) used at diagnosis to predict outcome. We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders) for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi- quantitativeimmunohistochemicalstudyandcorrelatedtheresultswiththeresponsetotreatment. Theresultsshowed that expression of bcl2 and CD20 in Hodgkin and Reed Sternberg cells, and expression of TiA1 in micro-environmental lymphocytes, and c-kit positive mast cells in microenvironment, were independent prognostic markers. These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorableprognosisandtobettertailortreatmentfordifferentriskgroups. Citation: Canioni D, Deau-Fischer B, Taupin P, Ribrag V, Delarue R, et al. (2009) Prognostic Significance of New Immunohistochemical Markers in R