Protective Effect of Total Flavonoids of Seabuckthorn (Hippophae rhamnoides) in Simulated High-Altitude Polycythemia in Rats 英文参考文献.docVIP

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Protective Effect of Total Flavonoids of Seabuckthorn (Hippophae rhamnoides) in Simulated High-Altitude Polycythemia in Rats 英文参考文献.doc

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Protective Effect of Total Flavonoids of Seabuckthorn (Hippophae rhamnoides) in Simulated High-Altitude Polycythemia in Rats 英文参考文献

Molecules 2012, 17, 11585-11597; doi:10.3390/molecules171011585 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Protective Effect of Total Flavonoids of Seabuckthorn (Hippophae rhamnoides) in Simulated High-Altitude Polycythemia in Rats Ji-Yin Zhou 1, Shi-Wen Zhou 1,*, Xiao-Huang Du 2 and Sheng-Ya Zeng 1 1 Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; E-Mails: zhoujiyin@ (J.-Y.Z.); zengshengya@ (S.-Y.Z.) 2 Research Division, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; E-Mail: duxiaohuang@163.com * Author to whom correspondence should be addressed; E-Mail: zhoushiwen2007@; Tel./Fax: +86-23-6875-5311. Received: 14 May 2012; in revised form: 4 September 2012 / Accepted: 4 September 2012 / Published: 28 September 2012 Abstract: Seabuckthorn (Hippophae rhamnoides L.) has been used to treat high altitude diseases. The effects of five-week treatment with total flavonoids of seabuckthorn (35, 70, 140 mg/kg, ig) on cobalt chloride (5.5 mg/kg, ip)- and hypobaric chamber (simulating 5,000 m)-induced high-altitude polycythemia in rats were measured. Total flavonoids decreased red blood cell number, hemoglobin, hematocrit, mean corpuscular hemoglobin levels, span of red blood cell electrophoretic mobility, aggregation index of red blood cell, plasma viscosity, whole blood viscosity, and increased deformation index of red blood cell, erythropoietin level in serum. Total flavonoids increased pH, pO2, SpO2, pCO2 levels in arterial blood, and increased Na+, HCO3?, Cl?, but decreased K+ concentrations. Total flavonoids increased mean arterial pressure, left ventricular systolic pressure, end-diastolic pressure, maximal rate of rise and decrease, decreased heart rate and protected right ventricle morphology. Changes in hemodynamic, hematologic parameters, and erythropoietin content suggest that administration of