Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy 英文参考文献.docVIP

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Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy 英文参考文献.doc

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Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy 英文参考文献

Clinical and Molecular Allergy BioMedCentral Research Open Access Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy Nacksung Kim1, Soon Seog Kwon2, Jaechun Lee3,4, Sohyung Kim4 and Tai June Yoo*4 Address: 1Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea, 2Department of Internal Medicine, Catholic University Medical School, Seoul, Korea, 3Department of Internal Medicine, College of Medicine, Cheju National University, Jeju, Korea and 4Division of Allergy/Immunology, Department of Medicine, University of Tennessee, Memphis, TN, USA Email: Nacksung Kim - nacksungkim@chonnam.ac.kr; Soon Seog Kwon - sskwon@; Jaechun Lee - doc4u@; Sohyung Kim - doctor4u@; Tai June Yoo* - tyoo@ * Corresponding author Published: 20 February 2006 Received: 11 October 2005 Accepted: 20 February 2006 Clinical and Molecular Allergy 2006, 4:4 doi:10.1186/1476-7961-4-4 This article is available from: /content/4/1/4 ? 2006 Kim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Vaccination with naked DNA encoding antigen induces cellular and humoral immunity characterized by the activation of specific Th1 cells. Objective: To evaluate the effects of vaccination with mixed naked DNA plasmids encoding Der p 1, Der p 2, Der p 3, Der f 1, Der f 2, and Der f 3, the major house dust mite allergens on the allergic inflammation to the whole house dust mites (HDM) crude extract. Methods: Three hundred micrograms of these gene mixtures were injected into muscle of BALB/ c mice. Control mice were injected with the pcDNA 3.1 blank vector. After 3 weeks, the mic