Pyometra in Bitches Induces Elevated Plasma Endotoxin and Prostaglandin F2α Metabolite Levels 英文参考文献.docVIP

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Pyometra in Bitches Induces Elevated Plasma Endotoxin and Prostaglandin F2α Metabolite Levels 英文参考文献.doc

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Pyometra in Bitches Induces Elevated Plasma Endotoxin and Prostaglandin F2α Metabolite Levels 英文参考文献

Acta vet. scand. 2006, 47, 55-68. Pyometra in Bitches Induces Elevated Plasma Endotoxin and Prostaglandin F2? Metabolite Levels By R. Hagman1, H. Kindahl2, A.-S. Lagerstedt1 1 Department of Small Animal Clinical Sciences, 2 Department of Clinical Sciences, Division of Comparative Reproduction, Obstetrics and Udder Health, Faculty of Veterinary Medicine, Swedish University of Agricul- tural Sciences, Box 7037, SE-75007 Uppsala, Sweden R. Hagman1, H. Kindahl2, A.-S. Lagerstedt1: Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F metabolite levels. Acta vet. scand. 2006, 2? 47, 55-68. – Endotoxemia in bitches with pyometra can cause severe systemic effects di- rectly or via the release of in?ammatory mediators. Plasma endotoxin concentrations were measured in ten bitches suffering from pyometra with moderately to severely de- teriorated general condition, and in nine bitches admitted to surgery for non-infectious reasons. Endotoxin samples were taken on ?ve occasions before, during and after surgery. In addition, urine and uterine bacteriology was performed and hematological, blood biochemical parameters, prostaglandin F metabolite 15-ketodihydro-PGF2? 2? (PG-metabolite), progesterone and oestradiol (E -17?) levels were analysed. 2 The results con?rm signi?cantly increased plasma levels of endotoxin in bitches with pyometra and support previous reports of endotoxin involvement in the pathogenesis of the disease. Plasma concentrations of PG-metabolite were elevated in pyometra bitches and provide a good indicator of endotoxin release since the concentrations were signif- icantly correlated to the endotoxin levels and many other hematological and chemistry parameters. The?-globulin serum protein electrophoresis fraction and analysis of PG- metabolite can be valuable in the diagnosis of endotoxin involvement if a reliable, rapid and cost-effective test for PG-metabolite analysis becomes readily available