Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures 英文参考文献.docVIP

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Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures 英文参考文献.doc

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Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures 英文参考文献

RecentEmergenceofStaphylococcusaureusClonal Complex398inHumanBloodCultures ErwinVerkade1,2*,AnnekeM.C.Bergmans1,3,AndriesE.Budding4,AlexvanBelkum5,6,PaulSavelkoul4, AntonG.Buiting2,JanKluytmans1,2,4 1Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands, 2Laboratory for Medical Microbiology and Immunology, St. Elisabeth Hospital,Tilburg,TheNetherlands,3LaboratoryforMicrobiology,FranciscusHospital,Roosendaal,TheNetherlands,4DepartmentofMedicalMicrobiology,VUUniversity medical centre, Amsterdam, The Netherlands, 5Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands, 6bioMe′rieux, MicrobiologyRandD,LaBalmeLesGrottes,France Abstract Background: Recently, a clone of MRSA with clonal complex 398 (CC398) has emerged that is related to an extensive reservoirinanimals,especiallypigsandvealcalves.Ithasbeenreportedpreviouslythatmethicillin-susceptiblevariantsof CC398circulateamonghumansatlowfrequency,andthesehavebeenisolatedinafewcasesofbloodstreaminfections (BSI).ThepurposeofthisstudywastodeterminetheprevalenceofS.aureusCC398inbloodculturestakenfrompatientsin ageographicareawithahighdensityofpigs. Methodology/Principal Findings: In total, 612 consecutive episodes of S. aureus BSI diagnosed before and during the emergence of CC398 were included. Three strains (2 MSSA and 1 MRSA) that were isolated from bacteremic patients between2010–2011werepositiveinaCC398specificPCR.TherewasamarkedincreaseinprevalenceofS.aureusCC398 BSIisolatedbetween2010–2011comparedtothecombinedcollectionsthatwereisolatedbetween1996–1998and2002– 2005(3/157,1.9%vs.0/455,0.0%;p =0.017). Conclusions/Significance: In conclusion, in anarea with arelative high density of pigs, S. aureus CC398 was found as a causeofBSIinhumansonlyrecently.ThisindicatesthatS.aureusCC398isabletocauseinvasiveinfectionsinhumansand that the prevalence is rising. Careful monitoring of the evolution and epidemiology of S. aureus CC398 in an