Recent HIV-1 Infection Contributes to the Viral Diffusion over the French Territory with a Recent Increasing Frequency 英文参考文献.docVIP
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Recent HIV-1 Infection Contributes to the Viral Diffusion over the French Territory with a Recent Increasing Frequency 英文参考文献
RecentHIV-1InfectionContributestotheViralDiffusion
overtheFrenchTerritorywithaRecentIncreasing
Frequency
PierreFrange1,2*,LaurenceMeyer3,ChristianeDeveau3,LaurentTran3,CecileGoujard3,4,JadeGhosn1,4
,
Pierre-MarieGirard5,PhilippeMorlat6,ChristineRouzioux1,7,Marie-LaureChaix1,7,fortheFrenchANRS
CO6PRIMOCohortStudyGroup
1Universite′ Paris-Descartes, Equipe d’accueil 3620, Sorbonne Paris Cite′, Paris, France, 2Unite′ d’immunologie, he′matologie et rhumatologie pe′diatriques, Assistance
Publique – Ho?pitaux de Paris, Ho?pital Necker – Enfants malades, Paris, France, 3INSERM, Unite′ 1018, Universite′ Paris-Sud, Faculte′ de Me′decine Paris-Sud, Service
d’Epide′miologie etdeSante′ Publique,AssistancePublique–Ho?pitauxdeParis,Ho?pitaldeBice?tre,LeKremlin-Bice?tre,France,4ServicedeMe′decineinterne,Assistance
Publique–Ho?pitauxdeParis,Ho?pitaldeBice?tre,LeKremlin-Bice?tre, France,5ServicedeMaladies infectieuseset tropicales, Assistance Publique–Ho?pitauxdeParis,
Ho?pital Saint Antoine, Paris, France, 6Service de Me′decine interne et maladies infectieuses, CHU de Bordeaux, Universite′ Bordeaux Segalen, Bordeaux, France,
7Laboratoiredevirologie,AssistancePublique–Ho?pitauxdeParis,Ho?pitalNecker–Enfantsmalades,Paris,France
Abstract
Objective: To analyse the contribution of primary human immunodeficiency virus type 1 (HIV-1) infection (PHI) to the
Frenchviralepidemic.
Methods:HIV-1polsequencesincluded987PHIfromtheFrenchANRSPRIMOcohortbetween1999and2010andwere
analysed using a population-based phylogenetic approach. Clinical features, risk factors, sexual behaviour and drug
resistanceforclusteredandnonclusteredtransmissioneventswereascertained.
Results:Virusesfrom125(12.7%)ofPHIcosegregatedinto56transmissionchains,withincreasingfrequencyduringthelast
years(10.2%before2006versus15.2%ofclustersin2006–2010,p=0.02).Themeannumberofpatientsperclusterwas
2.44.ComparedtouniquePHI,clustersinvolvedmoreoftenmen,infectedthroughhomosexualintercourse,ofyoungage,
withahighnumberofcasuals
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