RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals 英文参考文献.docVIP

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RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals 英文参考文献.doc

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RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals 英文参考文献

Open Access Research 2006FaghihiVolume and7, IssWahlestedtue 5, Article R38 RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals Mohammad Ali Faghihi*? and Claes Wahlestedt* Addresses: *Department of Biochemistry, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458, USA. ?Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius v?g, SE-171 77 Stockholm, Sweden. Correspondence: Claes Wahlestedt. Email: clawah@ Published: 9 May 2006 Received: 3 October 2005 Revised: 6 December 2005 Accepted: 13 April 2006 Genome Biology 2006, 7:R38 (doi:10.1186/gb-2006-7-5-r38) The electronic version of this article is the complete one and can be found online at /2006/7/5/R38 ? 2006 Faghihi and Wahlestedt; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Antisense-mediatedagpainTshtethsteuidnyvoflvtwmogeneeenxtaomfregulationplesRNAofi inendogenousthe naturalgenesanti ewithnse-mcodingediateord rnon-codingegulation ofnaturalmammantisensealian genetranscriptexpressiopartnersn./p provides evidence Abstract Background: Antisense transcription, yielding both coding and non-coding RNA, is a widespread phenomenon in mammals. The mechanism by which natural antisense transcripts (NAT) may regulate gene expression are largely unknown. The aim of the present study was to explore the mechanism of reciprocal sense-antisense (S-AS) regulation by studying the effects of a coding and non-coding NAT on corresponding gene expression, and to investigate the possible involvement of endogenous RNA interference (RNAi) in S-AS interactions. Results: We have examined the mechanism of S-AS RNA base pairing, using thymidylate synthase and hypoxia inducible