Salmonella paratyphi C Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi 英文参考文献.docVIP

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Salmonella paratyphi C Genetic Divergence from Salmonella choleraesuis and Pathogenic Convergence with Salmonella typhi 英文参考文献.doc

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SalmonellaparatyphiC:GeneticDivergencefrom SalmonellacholeraesuisandPathogenicConvergence withSalmonellatyphi Wei-QiaoLiu1,2.,YeFeng3,4.,YanWang2.¤a,Qing-HuaZou5,FangChen5,Ji-TaoGuo5,Yi-HongPeng5, YanJin2¤b,Yong-GuoLi6,Song-NianHu3,4,RandalN.Johnston7,Gui-RongLiu1,2,5*,Shu-LinLiu1,2,5,6 * 1Genomics Research Center, Harbin Medical University, Harbin, China, 2Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada, 3JD WatsonInstituteofGenomeSciences,ZhejiangUniversity,Hangzhou,China,4BeijingInstituteofGenomics,ChineseAcademyofSciences,Beijing,China,5Department of Microbiology, Peking University Health Science Center, Beijing, China, 6Depatment of Infectious Diseases, First Hospital, Harbin Medical University, Harbin, China, 7DepartmentsofBiochemistryandMolecularBiology,UniversityofCalgary,Calgary,Alberta,Canada Abstract Background: Although over 1400 Salmonella serovars cause usually self-limited gastroenteritis in humans, a few, e.g., SalmonellatyphiandS.paratyphiC,causetyphoid,apotentiallyfatalsystemicinfection.Itisnotknownwhetherthetyphoid agentshaveevolvedfromacommonancestor(bydivergentprocesses)oracquiredsimilarpathogenictraitsindependently (by convergent processes). Comparison of different typhoid agents with non-typhoidal Salmonella lineages will provide excellentmodelsforstudiesonhowsimilarpathogensmighthaveevolved. Methodologies/Principal Findings: We sequenced a strain of S. paratyphi C, RKS4594, and compared it with previously sequencedSalmonellastrains.RKS4594containsachromosomeof4,833,080bpandaplasmidof55,414bp.Wepredicted 4,640 intact coding sequences (4,578 in the chromosome and 62 in the plasmid) and 152 pseudogenes (149 in the chromosomeand3intheplasmid).RKS4594 sharesasmanyas4346 ofthe4,640geneswithastrain of S.choleraesuis, whichisprimarilyaswinepathogen,butonly4008geneswithanotherhuman-adaptedtyphoidagent,S.typhi .Comparison of 3691 genes shared by all six sequenced Salmonella strains placed S. paratyphi C a