Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine 英文参考文献.docVIP

下载本文档

3
0
约4.13万字
约 7页
2017-05-13 发布于上海
举报
版权申诉

Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the Intestine 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

SalmonellaPathogenicityIsland2 IsExpressedPriortoPenetrating theIntestine Nat F.Brown1[,Bruce A.Vallance2[,Brian K.Coombes1,Yanet Valdez1,Bryan A.Coburn1,B.Brett Finlay1* 1MichaelSmithLaboratories,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada,2DivisionofGastroenterology,BCChildren’sHospital,Vancouver,British Columbia,Canada Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that causes disease in mice that resembleshumantyphoid.Typhoidpathogenesisconsistsofdistinctphasesintheintestineandasubsequentsystemic phasein which bacteria replicate in macrophages of theliver and spleen. The type IIIsecretion system encoded by Salmonella pathogenicity island 2 (SPI-2) is a major virulence factor contributing to the systemic phase of typhoid pathogenesis. Understanding how pathogens regulate virulence mechanisms in response to the environment, includingdifferenthosttissues,iskeytoourunderstandingofpathogenesis.Arecombinase-basedinvivoexpression technologysystemwasdevelopedtoassessSPI-2expressionduringmurinetyphoid.SPI-2expressionwasdetectable atveryearlytimesinbacteriathatwereresidentinthelumenoftheileumandwasindependentofactivebacterial invasionoftheepithelium.WealsoprovidedirectevidencefortheregulationofSPI-2bytheSalmonellatranscription factorsompRandssrBinvivo.TogethertheseresultsdemonstratethatSPI-2expressionprecedespenetrationofthe intestinalepithelium.ThisinductionofexpressionprecedesanydocumentedSPI-2-dependentphasesoftyphoidand may be involved in preparing Salmonella to successfully resist the antimicrobial environment encountered within macrophages. Citation: BrownNF,Vallance BA,CoombesBK,Valdez Y,CoburnBA,etal.(2005) Salmonella pathogenicityisland2isexpressed priortopenetrating the intestine.PLoS Pathog1(3):e32. where they alter various host cell processes [6]. The T3SS encoded by Salmonella pathogenicity island 1 (SPI-1) allows Introduction Salmonella is a Gram-negative bacterial pathogen that causes substant