Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia Findings from the National Health and Nutrition Examination Survey III 英文参考文献.docVIP

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Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia Findings from the National Health and Nutrition Examination Survey III 英文参考文献.doc

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Sarcopenia Exacerbates Obesity-Associated Insulin Resistance and Dysglycemia Findings from the National Health and Nutrition Examination Survey III 英文参考文献

SarcopeniaExacerbatesObesity-AssociatedInsulin ResistanceandDysglycemia:FindingsfromtheNational HealthandNutritionExaminationSurveyIII PreethiSrikanthan1*,AndreaL.Hevener2,ArunS.Karlamangla1 1Division of Gerontology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America,2DivisionofEndocrinology,Diabetes,andHypertension,DepartmentofMedicine,DavidGeffenSchoolofMedicine,UniversityofCaliforniaLosAngeles,Los Angeles,California,UnitedStatesofAmerica Abstract Background:Sarcopeniaoftenco-existswithobesity,andmayhaveadditiveeffectsoninsulinresistance.Sarcopenicobese individuals could be at increased risk for type 2 diabetes. We performed a study to determine whether sarcopenia is associatedwithimpairmentininsulinsensitivityandglucosehomeostasisinobeseandnon-obeseindividuals. Methodology:Weperformedacross-sectionalanalysisofNationalHealthandNutritionExaminationSurveyIIIdatautilizing subjects of 20 years or older, non-pregnant (N=14,528). Sarcopenia was identified from bioelectrical impedance measurement of muscle mass. Obesity was identified from body mass index. Outcomes were homeostasis model assessmentofinsulinresistance(HOMAIR),glycosylatedhemoglobinlevel(HbA1C),andprevalenceofpre-diabetes(6.0# HbA1C,6.5 and not on medication) and type 2 diabetes. Covariates in multiple regression were age, educational level, ethnicityandsex. PrincipalFindings:Sarcopeniawasassociatedwithinsulinresistanceinnon-obese(HOMAIRratio1.39,95%confidence interval(CI)1.26to1.52)andobeseindividuals(HOMA-IRratio1.16,95%CI1.12to1.18).Sarcopeniawasassociatedwith dysglycemiainobeseindividuals(HbA1Cratio1.021,95%CI1.011to1.043)butnotinnon-obeseindividuals.Associations werestrongerinthoseunder60yearsofage.Weacknowledgethatthecross-sectionalstudydesignlimitsourabilityto drawcausalinferences. Conclusions: Sarcopenia, independent of obesity, is associated with adverse glucose metabolism, and the association is stron