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Salivary uric acid as a noninvasive biomarker of metabolic syndrome 英文参考文献
Soukupetal.DiabetologyMetabolicSyndrome2012,4:14
/content/4/1/14
DIABETOLOGY
METABOLIC SYNDROME
SHORT REPORT
OpenAccess
Salivaryuricacidasanoninvasivebiomarkerof
metabolicsyndrome
MariaSoukup1,IzabelaBiesiada1,AaronHenderson2,BenmichaelIdowu1,DerekRodeback1,LanceRidpath3,
EdwardGBridges1,AndreaM.Nazar4andKristieGroveBridges1*
Abstract
Background:Elevatedserumuricacidisassociatedwithobesity,hypertensionandmetabolicsyndrome.Becausea
linearrelationshipexistsbetweenserumandsalivaryuricacid(SUA)concentration,salivatestingmaybeauseful
noninvasiveapproachformonitoringcardiometabolicrisk.ThegoalofthispilotstudywastodetermineifSUAis
increasedinpatientswithmetabolicsyndromeandtoinvestigatecorrelationsbetweenSUAandindividual
cardiometabolicriskfactors.
Findings:Volunteersbetweentheagesof18and65withoutconditionsknowntoaffectserumuricacidlevelswere
recruited.Height,weight,bloodpressureandwaistcircumferenceweremeasuredandafulllipidpanelalongwithfasting
bloodglucosewasobtained.Salivasampleswerecollectedanduricacidlevelsweredetermined.78volunteers,35%of
whomhadmetabolicsyndrome,completedthestudy.SUAwassignificantlyelevatedinpatientswithmetabolic
syndrome(p=.002).Theincidenceofmetabolicsyndromeinthe4thquartileforSUAwas67%comparedto25%in
quartiles1-3combined.SignificantcorrelationswereseenbetweenSUAandsystolicbloodpressure(r=.440,p=.000),
diastolicbloodpressure(r=.304,p=.007),waistcircumference(r=.332,p=.003),BMI(r=.269,p=.018),fastingblood
glucose(r=.341,p=.002),triglycerides(r=.410,p=.000),HDL(r=?.237,p=.036)andthenumberofcardiometabolic
riskfactorspresent(r=0.257,p=.023).
Conclusions:TheseresultssuggestthatSUAmaybeausefulbiomarkerfornoninvasivemonitoringofcardiometabolic
risk.Largerstudiesareneededtovalidatethisapproach.
Keywords:Saliva,Biomarker,Metabolicsyndrome,Uricacid
Findings
Introduction
bloodpressure,elevatedtriglycerides(TRG),reducedhigh
density lipoproteins (HDL), and impaired fasting blood
Theimpactofobesityonhealthoutcomescanbeseenin glucose(IFG)[2].Patients
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