Salivary pH as a marker of plasma adiponectin concentrations in Women 英文参考文献.docVIP

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Salivary pH as a marker of plasma adiponectin concentrations in Women 英文参考文献.doc

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Tremblayetal.DiabetologyMetabolicSyndrome2012,4:4 /content/4/1/4 DIABETOLOGY METABOLIC SYNDROME RESEARCH OpenAccess SalivarypHasaMarkerofPlasmaAdiponectin ConcentrationsinWomen MoniqueTremblay,YacineLoucif,JulieMethot,DianeBrissonandDanielGaudet* Abstract Background:Plasmaadiponectinisasignificantcorrelateofthepro-inflammatorycardiometabolicriskprofile associatedwithobesityandtype2diabetes.SalivarypHisinfluencedbyseveralcardiometabolicriskcomponents suchasinflammation,oxidationandnumerousoralandsystemichealthmodulators,includingthemenopausal status.ThisstudyaimedtoassesstheassociationbetweenplasmaadiponectinconcentrationsandsalivarypHin womenaccordingtothemenopausalstatus. Method:Unstimulatedsalivacollectionwasperformedin151CaucasianwomenofFrench-Canadianorigin(53 premenopausalwomen(PMW)and98menopausalwomen(MW)).Student’sttest,ANOVAandlinearregression modelswereusedtoassesstheassociationbetweenplasmaadiponectinconcentrationsandsalivarypH. Results:PlasmaadiponectinlevelsincreasedasafunctionofsalivarypHinthewholesampleandamongMW(r=0.29 andr=0.36,p0.001).TheproportionofthevarianceofplasmaadiponectinlevelsexplainedbythesalivarypH(R2) was10.8%(p0.001).PlasmaadiponectinlevelsprogressivelyincreasedacrosssalivarypHquartiles(p=0.005). Conclusions:TheseresultssuggestthatsalivarypHisasignificantcorrelateofplasmaadiponectinlevelsin women.Withtheincreasingprevalenceoftype2diabetesandobesity,newtechnologiesshouldbedevelopedto moreeasilymonitorhealthstatus,diseaseonsetandprogression.SalivarypH,asimple,inexpensiveandnon- invasivemeasure,couldbeaverypromisingavenue. Keywords:SalivarypH,Adiponectin,Cardiometabolicrisk,Diabetes Introduction Adiponectinhasbeenidentifiedasanewbiochemical According to the World Health Organization, by 2015 markerofvisceralfataccumulationandcouldrepresenta approximately2.3billionadultsworldwidewillbeover- criticallinkbetweenobesityandthecardiometabolicrisk weight and more than 700 million obese [1]. The bur- profile[3].Adiponectinisanadipocyte-