Schizophrenia as Failure of Left Hemispheric Dominance for the Phonological Component of Language 英文参考文献.docVIP

SchizophreniaasFailureofLeftHemisphericDominance forthePhonologicalComponentofLanguage AlessandroAngrilli1,2*,ChiaraSpironelli1,ThomasElbert3,TimothyJ.Crow4,GianfrancoMarano5, LucianoStegagno1 1Department of General Psychology, University of Padova, Padova, Italy, 2CNR Institute of Neuroscience, Padova, Italy, 3Center for Psychiatry, Reichenau and DepartmentofPsychology,UniversityofKonstanz,Konstanz,Germany,4SANEPOWIC,DepartmentofPsychiatry,WarnefordHospital,Oxford,UnitedKingdom,5Center forEatingDisorders,ULSS18,Rovigo,Italy Abstract Background:T.J.CrowsuggestedthatthegeneticvarianceassociatedwiththeevolutioninHomosapiensofhemispheric dominance for language carries with it the hazard of the symptoms of schizophrenia. Individuals lacking the typical left hemisphereadvantageforlanguage,inparticularforphonologicalcomponents,wouldbeatincreasedriskofthetypical symptomssuchasauditoryhallucinationsanddelusions. Methodology/Principal Findings: Twelve schizophrenic patients treated with low levels of neuroleptics and twelve matchedhealthycontrolsparticipatedinanevent-relatedpotentialexperiment.Subjectsmatchedword-pairsinthreetasks: rhyming/phonological, semantic judgment and word recognition. Slow evoked potentials were recorded from 26 scalp electrodes,andalateralityindexwascomputedforanteriorandposteriorregionsduringtheinterstimulusinterval.During phonological processing individuals with schizophrenia failed to achieve the left hemispheric dominance consistently observed in healthy controls. The effect involved anterior (fronto-temporal) brain regions and was specific for the Phonological task; group differences were small or absent when subjects processed the same stimulus material in a Semantic task or during Word Recognition, i.e. during tasks that typically activate more widespread areas in both hemispheres. Conclusions/Significance:Weshowforthefirsttimehowthedeficitoflateralizationintheschizophrenicbrainisspecific for the phonological component of language. This los