Science Review Vasopressin and the cardiovascular system part 2 – clinical physiology 英文参考文献.docVIP

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Science Review Vasopressin and the cardiovascular system part 2 – clinical physiology 英文参考文献.doc

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Science Review Vasopressin and the cardiovascular system part 2 – clinical physiology 英文参考文献

Available online /content/8/1/15 Review Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology Cheryl L Holmes1, Donald W Landry2 and John T Granton3 1Staff intensivist, Department of Medicine, Division of Critical Care, Kelowna General Hospital, Kelowna BC, Canada 2Associate Professor, Department of Medicine, Columbia University, New York, New York, USA 3Assistant Professor of Medicine, Faculty of Medicine, and Program Director, Critical Care Medicine, University of Toronto, and Consultant in Pulmonary and Critical Care Medicine, Director Pulmonary Hypertension Program, University Health Network, Toronto, Ontario, Canada Corresponding author: John T Granton, John.Granton@uhn.on.ca Published online: 26 June 2003 Critical Care 2004, 8:15-23 (DOI 10.1186/cc2338) This article is online at /content/8/1/15 ? 2004 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Vasopressin is emerging as a rational therapy for vasodilatory shock states. In part 1 of the review we discussed the structure and function of the various vasopressin receptors. In part 2 we discuss vascular smooth muscle contraction pathways with an emphasis on the effects of vasopressin on ATP- sensitive K+ channels, nitric oxide pathways, and interaction with adrenergic agents. We explore the complex and contradictory studies of vasopressin on cardiac inotropy and coronary vascular tone. Finally, we summarize the clinical studies of vasopressin in shock states, which to date have been relatively small and have focused on physiologic outcomes. Because of potential adverse effects of vasopressin, clinical use of vasopressin in vasodilatory shock should await a randomized controlled trial of the effect of vasopressin’s effect on outcomes such as organ failure and mortality. Keywords adrenergic agents, antidiurectic hormone, cardiac inotropy, hypotension, nitric oxide, oxytocin, physiology, potassium channels, receptor