SDF1 Gene Variation Is Associated with Circulating SDF1α Level and Endothelial Progenitor Cell Number–The Bruneck Study 英文参考文献.docVIP

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SDF1 Gene Variation Is Associated with Circulating SDF1α Level and Endothelial Progenitor Cell Number–The Bruneck Study 英文参考文献.doc

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SDF1 Gene Variation Is Associated with Circulating SDF1α Level and Endothelial Progenitor Cell Number–The Bruneck Study 英文参考文献

SDF1GeneVariationIsAssociatedwithCirculating SDF1aLevelandEndothelialProgenitorCellNumber– TheBruneckStudy QingzhongXiao1,ShuYe2,FriedrichOberhollenzer3,AgnesMayr3,MarjanJahangiri4,JohannWilleit5, StefanKiechl5,QingboXu1* 1CardiovascularDivision,King’sCollegeLondonBHFCentre,London,UnitedKingdom,2BartsandtheLondonSchoolofMedicineandDentistry,QueenMaryUniversity ofLondon,London,UnitedKingdom,3DepartmentofInternalandLaboratoryMedicine,BruneckHospital,Bruneck,Italy,4DepartmentofCardiothoracicSurgery,St. George’sHospital,London,UnitedKingdom,5DepartmentofNeurology,MedicalUniversityofInnsbruck,Innsbruck,Austria Abstract Background:Stromalcell-derivedfactor-1(SDF1)anditsreceptorCXCchemokinereceptor4(CXCR4)playacriticalrolein progenitorcellhoming,mobilizationanddifferentiation.ItwouldbeinterestingtoassessthepredictivevalueofSDF-1alpha levelforEPC number,andtoascertainwhetherthereisarelationship between SDF1genevariation,plasma SDF-1alpha level,andthenumberandfunctionofcirculatingEPCs.WealsotestedwhetherEPCnumberandfunctionwasrelatedto CXCR4genevariation. Methodology and Principal Findings: We genotyped a cohort of individuals who participated in the Bruneck Study for single nucleotide polymorphisms (SNPs) in the SDF1 and CXCR4 genes, and measured blood SDF1a level as well as EPC number and function. SDF1a levels were correlated with age, gender, alcohol consumption, circulating reticulocyte numbers,andconcentrationsofmatrixmetalloproteinase-9,C-reactiveprotein,cystatinC,fibrinogenandhomocytein.In bloodsamplestakenin2005,EPCnumberwasinverselyassociatedwithSDF1alevel(p,0.001).EPCnumberin2005was alsoinverselyassociatedwithSDF1alevelin2000(p=0.009),suggestingapredictivevalueofplasmaSDF1alevelforEPC number.TherewasanassociationbetweentheSDF1geners2297630SNPA/Agenotype,increasedSDF1alevel(p=0.002) andlowerEPCnumber(p=0.006). Conclusions:OurdataindicatethataSDF1genevariation(rs2297630)hasaninfluenceonSDF1alevelandcirculatingEPC number,andthatplasmaSDF1alevelisapredictorofE