Scutellaria baicalensis decreases ritonavir-induced nausea 英文参考文献.docVIP

AIDS Research and Therapy BioMedCentral Research Open Access Scutellaria baicalensis decreases ritonavir-induced nausea Han Aung1,2, Sangeeta Mehendale1,2, Wei-Tien Chang1,2, Chong-Zhi Wang1,2, Jing-Tian Xie1,2 and Chun-Su Yuan*1,2,3 Address: 1Tang Center for Herbal Medicine Research, Pritzker School of Medicine. The University of Chicago, IL 60637, USA, 2Departments of Anesthesia Critical Care. Pritzker School of Medicine. The University of Chicago, IL 60637, USA and 3Committee on Clinical Pharmacology and Pharmacogenomics. Pritzker School of Medicine. The University of Chicago, IL 60637, USA Email: Han Aung - haung@; Sangeeta Mehendale - smehendale@; Wei- Tien Chang - wchang@; Chong-Zhi Wang - czwang@; Jing-Tian Xie - jtxie@; Chun-Su Yuan* - cyuan@ * Corresponding author Published: 20 December 2005 Received: 15 August 2005 Accepted: 20 December 2005 AIDS Research and Therapy 2005, 2:12 doi:10.1186/1742-6405-2-12 This article is available from: /content/2/1/12 ? 2005 Aung et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Protease inhibitors, particularly ritonavir, causes significant gastrointestinal disturbances such as nausea, even at low doses. This ritonavir-induced nausea could be related to its oxidative stress in the gut. Alleviation of drug-induced nausea is important in effectively increasing patients compliance and improving their quality of life. Conventional anti-emetic drugs can only partially abate the symptoms in these patients, and their cost has also been a concern. Rats respond to nausea-producing emetic stimuli by increasing consumption of non-nutritive substances like kaolin or clay, a phenomenon known as pica. In this study, we used this