Search for an Association between V249I and T280M CX3CR1 Genetic Polymorphisms, Endothelial Injury and Preeclampsia The ECLAXIR Study 英文参考文献.docVIP
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Search for an Association between V249I and T280M CX3CR1 Genetic Polymorphisms, Endothelial Injury and Preeclampsia The ECLAXIR Study 英文参考文献
SearchforanAssociationbetweenV249IandT280M
CX3CR1GeneticPolymorphisms,EndothelialInjuryand
Preeclampsia:TheECLAXIRStudy
AlainStepanian1,8,SorayaBenchenni1,TiphaineBeillat-Lucas2,SophieOmnes3,FannieDefay4 ,Edith
Peynaud-Debayle1,8,GabrielBaron4,Agne`sLeQuerrec5,MichelDreyfus2,LaurenceSalomon10 ,Vassilis
Tsatsaris6,DominiquedeProst1,8,9*,LaurentMandelbrot7,9 fortheECLAXIRstudygroup
1AP-HP, Ho?pital Louis Mourier, Service d’He′matologie Biologique, Colombes, France, 2CHU Cle′menceau, Unite′ de Gyne′cologie-Obste′trique et Me′decine de la
Reproduction, Caen, France, 3AP-HP, Ho?pital Bichat-Claude-Bernard, Service de Gyne′cologie-Obste′trique, Paris, France, 4AP-HP, Ho?pital Bichat-Claude Bernard,
De′partementd’Epide′miologie,BiostatistiqueetRechercheClinique,Paris,France,5CHUCo?tedeNacre,Serviced’He′matologieBiologique,Caen,France,6AP-HP,Groupe
Hospitalier Cochin Saint-Vincent de Paul, Service de Gyne′cologie-Obste′trique, Paris, France, 7AP-HP, Ho?pital Louis Mourier, Service de Gyne′cologie-Obste′trique,
Colombes,France,8CIBPhe′nogenduGHUNord,Paris,France,9Universite′ Paris7–DenisDiderot,Paris,France,10AP-HP,Ho?pitalLouisMourier,De′partementdeSante′
Publique(Evaluation,RechercheClinique,Informationme′dicale, Vigilances)–(DIM),Colombes,France
Abstract
Background: Preeclampsia and coronary-artery disease share risk factors, suggesting common pathophysiological
mechanisms.CX3CR1/CX3CL1mediatesleukocytemigrationandadhesionandhasbeenimplicatedinthepathophysiology
ofseveralinflammatorydiseases.M280/I249variantsofCX3CR1areassociatedwithanatheroprotectiveeffectandreduced
endothelialdysfunction.TheaimofthisstudywastosearchforanassociationbetweenV249IandT280Mpolymorphismsof
CX3CR1,preeclampsiaandendothelialdysfunction.
Methodology/PrincipalFindings:Weexploredthesepolymorphismswithreal-timepolymerasechainreactioninacase-
control study (184 white women with preeclampsia and 184 matched normotensive pregnant women). Endothelial
dysfunction biomarkers including von Will
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