Secretome clues into pathogen infection and clinical applications 英文参考文献.docVIP

Review Secretome: clues into pathogen infection and clinical applications Shoba Ranganathan*? and Gagan Garg* Addresses: *Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics, Macquarie University, Sydney NSW 2109, Australia. ?Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597 Singapore. Correspondence: Shoba Ranganathan. Email: shoba.ranganathan@.au A brief overview of the currently available methods for generating and analyzing pathogen secretome data is pre- sented, followed by a critical analysis of their contribution Abstract The secretome encompasses the complete set of gene products secreted by a cell. Recent studies on secretome analysis reveal to our understanding of pathogen infection and host responses, especially in comparison to other genome analysis approaches. Some early successes in the applica- tions of secretome data in the areas of therapeutic target identification, diagnostic tools and pathogen control are also presented. that secretory proteins play an important role in pathogen infection and host-pathogen interactions. Excretory/secretory proteins of pathogens change the host cell environment by suppressing the immune system, to aid the proliferation of infection. Identifying secretory proteins involved in pathogen infection will lead to the discovery of potential drug targets and biomarkers for diagnostic applications. Introduction Approaches for secretome analysis The secretome constitutes the entire set of secreted Genome sequence analysis proteins, representing up to 30% of the proteome of an organism [1], and includes functionally diverse classes of Genome sequence analysis is based on transcript profiling and computational analysis. The computational prediction of secreted proteins s