Season of birth, clinical manifestations and Dexamethasone Suppression Test in unipolar major depression 英文参考文献.docVIP

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Season of birth, clinical manifestations and Dexamethasone Suppression Test in unipolar major depression 英文参考文献.doc

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Season of birth, clinical manifestations and Dexamethasone Suppression Test in unipolar major depression 英文参考文献

Annals of General Psychiatry BioMedCentral Primary research Open Access Season of birth, clinical manifestations and Dexamethasone Suppression Test in unipolar major depression Konstantinos N Fountoulakis*1, Apostolos Iacovides1, Michael Karamouzis2, George S Kaprinis1 and Charalambos Ierodiakonou1 Address: 1Third Department of Psychiatry, Aristotle University of Thessaloniki, Greece and 2Laboratory of Biochemistry, Aristotle University of Thessaloniki, Greece Email: Konstantinos N Fountoulakis* - kfount@med.auth.gr; Apostolos Iacovides - iacovid@med.auth.gr; Michael Karamouzis - mkaram@med.auth.gr; George S Kaprinis - kaprinis@med.auth.gr; Charalambos Ierodiakonou - kfount@med.auth.gr * Corresponding author Published: 3 August 2007 Received: 9 March 2007 Accepted: 3 August 2007 Annals of General Psychiatry 2007, 6:20 doi:10.1186/1744-859X-6-20 This article is available from: /content/6/1/20 ? 2007 Fountoulakis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Reports in the literature suggest that the season of birth might constitute a risk factor for the development of a major psychiatric disorder, possibly because of the effect environmental factors have during the second trimester of gestation. The aim of the current paper was to study the possible relationship of the season of birth and current clinical symptoms in unipolar major depression. Methods: The study sample included 45 DSM-IV major depressive patients and 90 matched controls. The SCAN v. 2.0, Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Scale (HAS) were used to assess symptomatology, and the 1 mg Dexamethasone Suppression Test (DST) was used to subcategorize patients. Results