Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach 英文参考文献.docVIP

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Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach 英文参考文献.doc

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SelectionforHighOridoninYieldintheChinese MedicinalPlantIsodon(Lamiaceae)UsingaCombined PhylogeneticsandPopulationGeneticsApproach EricS.J.Harris1,2*,ShugengCao1,2,SeanD.Schoville3,ChengmingDong4,WenquanWang5,ZaiyouJian6, ZhongzhenZhao7,DavidM.Eisenberg2,8,JonClardy1 1DepartmentofBiologicalChemistryandMolecularPharmacology,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,2OsherResearchCenter, HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica,3UniversiteèJosephFourierGrenoble,CentreNationaldelaRechercheScientifiqueTIMC-IMAG UMR5525,EquipeBiologieComputationnelleetMatheèmatique,Grenoble,France,4CollegeofPharmacy,HenanCollegeofTraditionalChineseMedicine,Zhengzhou, Henan, PR China, 5School of Chinese Pharmacy, Beijing University of Chinese Medicine, Chaoyang District Beijing, PR China, 6School of Biological Science and Technology, Henan Institute of Science and Technology, Hualan Dao, Xinxiang City, Henan, PR China, 7School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, PR China, 8Department of Medicine, Division of General Internal Medicine, Beth Israel Deaconess Medical Center,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract Oridoninisaditerpenoidwithanti-canceractivitythatoccursintheChinesemedicinalplantIsodonrubescensandsome relatedspecies.Whilethebioactivityoforidoninhasbeenwellstudied,theextentofnaturalvariationintheproductionof thiscompoundispoorlyknown.Thisstudycharacterizesnaturalvariationinoridoninproductioninordertoguideselection ofpopulationsofIsodonwithhighestoridoninyield.DifferentpopulationsofI.rubescensandrelatedspecieswerecollected inChina,andtheiroffspringweregrowninagreenhouse.Sampleswereexaminedfororidonincontent,genotypedusing 11 microsatellites, and representatives were sequenced for three phylogenetic markers (ITS, rps16, trnL-trnF ). Oridonin production was mapped on a molecular phylogeny of the genus Isodon using samples from each po