Selection for tameness modulates the expression of heme related genes in silver foxes 英文参考文献.docVIP

Behavioral and Brain Functions BioMedCentral Research Open Access Selection for tameness modulates the expression of heme related genes in silver foxes Julia Lindberg1,3, Susanne Bj?rnerfeldt1, Morten Bakken2, Carles Vilà1, Elena Jazin3 and Peter Saetre*3 Address: 1Department of Evolution, Genomics and Systematics, Uppsala University, Norbyv?gen 18D, S-752 36 Uppsala, Sweden, 2Department of Animal and Aquacultural Sciences, Norwegian University of Life Science, P.O. Box 5003 N-1432 Aas, Norway and 3Department of Physiology and Developmental Biology, Uppsala University, Norbyv?gen 18A, S-752 36 Uppsala, Sweden Email: Julia Lindberg - Julia.Lindberg@ebc.uu.se; Susanne Bj?rnerfeldt - Susanne.Bjornerfeldt@ebc.uu.se; Morten Bakken - Morten.Bakken@umb.no; Carles Vilà - Carles.Vila@ebc.uu.se; Elena Jazin - Elena.Jazin@ebc.uu.se; Peter Saetre* - Peter.Saetre@ebc.uu.se * Corresponding author Published: 17 April 2007 Received: 24 January 2007 Accepted: 17 April 2007 Behavioral and Brain Functions 2007, 3:18 doi:10.1186/1744-9081-3-18 This article is available from: /content/3/1/18 ? 2007 Lindberg et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The genetic and molecular mechanisms of tameness are largely unknown. A line of silver foxes (Vulpes vulpes) selected for non-aggressive behavior has been used in Russia since the 1960s to study the effect of domestication. We have previously compared descendants of these selected (S) animals with a group of non-selected (NS) silver foxes kept under identical conditions, and showed that changes in the brain transcriptome between the two groups are small. Unexpectedly, many of the genes showing evidence of differential expression between