Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome 英文参考文献.docVIP

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Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome 英文参考文献.doc

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Sensory Dysfunction of Bladder Mucosa and Bladder Oversensitivity in a Rat Model of Metabolic Syndrome 英文参考文献

SensoryDysfunctionofBladderMucosaandBladder OversensitivityinaRatModelofMetabolicSyndrome Wei-ChiaLee1,Po-HuiChiang1,You-LinTain2,Chia-ChingWu3,Yao-ChiChuang1* 1Division of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 2Department of pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, 3Department of International Business, College of CommerceandManagement,ChengShiuUniversity,Kaohsiung,Taiwan Abstract Purpose: To study the role of sensory dysfunction of bladder mucosa in bladder oversensitivity of rats with metabolic syndrome. Materials andMethods: FemaleWistarratswerefedafructose-richdiet(60%)oranormaldietfor3months.Basedon cystometry,thefructose-fedrats(FFRs)weredividedintoagroupwithnormaldetrusorfunctionordetrusoroveractivity (DO). Acidic adenosine triphosphate (ATP) solution (5mM, pH3.3) was used to elicit reflex micturition. Cystometric parameterswereevaluatedbeforeandafterdrugadministration.Functionalproteinsofthebladdermucosawereassessed bywesternblotting. Results: Comparedtothecontrols,intravesicalacidicATPsolutioninstillationinducedasignificantincreaseinprovoked phasiccontractionsinbothFFRgroupsandasignificantdecreaseinthemeanfunctionalbladdercapacityofgroupDO. PretreatmentwithcapsaicinforC-fiberdesentization,intravesicalliposomeformucosalprotection,orintravenouspyridoxal 5-phosphate 6-azophenyl-29,49-disulfonic acid for antagonized purinergic receptors can interfere with the urodynamic effectsofintravesicalATPinFFRsandcontrols.Over-expressionofTRPV1,P2X3,andiNOSproteins,anddown-regulationof eNOSproteinswereobservedinthebladdermucosaofbothfructose-fedgroups. Conclusions: Alterations of sensory receptors and enzymes in the bladder mucosa, including over-expression of TRPV1, P2X3, and iNOS proteins, can precipitate the emergence of bladder phasic contractions and oversensitivity through the activationofC-afferentsduringacidicAT