Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp 英文参考文献.docVIP

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Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp 英文参考文献.doc

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Short-termeffectsofamelogeningenespliceproductsA4andA-4implantedintheexposedratmolarpulp英文参考文献

Head Face Medicine BioMedCentral Research Open Access Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp Nadège Jegat1, Dominique Septier1, Arthur Veis2, Anne Poliard3 and Michel Goldberg*1 Address: 1Oral Biology, EA 2496, Faculté de Chirurgie Dentaire, Université Paris Descartes, Montrouge, France, 2Feinberg School of Medicine, Northwestern University, Chicago, USA and 3Laboratoire de Différenciation, Cellules Souches et Prions, CNRS-FRE2937, Villejuif Cedex, France Email: Nadège Jegat - nadjeg@wanadoo.fr; Dominique Septier - dseptier@; Arthur Veis - aveis@; Anne Poliard - apoliard@rs.fr; Michel Goldberg* - mgoldod@ * Corresponding author Published: 21 December 2007 Received: 4 December 2007 Accepted: 21 December 2007 Head Face Medicine 2007, 3:40 doi:10.1186/1746-160X-3-40 This article is available from: /content/3/1/40 ? 2007 Jegat et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract In order to study the short-time effects of two bioactive low-molecular amelogenins A+4 and A-4, half-moon cavities were prepared in the mesial aspect of the first maxillary molars, and after pulp exposure, agarose beads alone (controls) or beads soaked in A+4 or A-4 (experimental) were implanted into the pulp. After 1, 3 or 7 days, the rats were killed and the teeth studied by immunohistochemistry. Cell proliferation was studied by PCNA labeling, positive at 3 days, but decreasing at day 7 for A+4, whilst constantly high between 3 and 7 days for A-4. The differentiation toward the osteo/odontoblast lineage shown by RP59 labeling was more apparent for A-4 compared with A+4. Osteopontin-positive cells were alike at days 3 and 7 fo