Significantly Reduced Intensity of Infection but Persistent Prevalence of Schistosomiasis in a Highly Endemic Region in Mali after Repeated Treatment 英文参考文献.docVIP

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Significantly Reduced Intensity of Infection but Persistent Prevalence of Schistosomiasis in a Highly Endemic Region in Mali after Repeated Treatment 英文参考文献.doc

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Significantly Reduced Intensity of Infection but Persistent Prevalence of Schistosomiasis in a Highly Endemic Region in Mali after Repeated Treatment 英文参考文献

SignificantlyReducedIntensityofInfectionbut PersistentPrevalenceofSchistosomiasisinaHighly EndemicRegioninMaliafterRepeatedTreatment AlyLandoure′1,RobertDembe′le′2,SeydouGoita3,MamadouKane′4,MarjonTuinsma3,MoussaSacko1, EmilyToubali5,MichaelD.French6,AdamaD.Keita7,AlanFenwick6,MamadouS.Traore′1,8,YaobiZhang9* 1InstitutNationaldeRechercheenSante′Publique,BP1771,Bamako,Mali,2ProgrammeNationaldeLutteContrelesSchistosomiasesetlesGeohelminthes,Ministe`rede laSante′,Bamako,Mali,3HelenKellerInternational,Bamako,Mali,4Ho?pitalduMali,Ministe`redelaSante′,Bamako,Mali,5HelenKellerInternational,NewYork,NewYork, United States of America, 6Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom, 7Ho?pital National du Point G, Centre Hospitalier Universitaire,Bamako,Mali,8Faculte′ deMe′decinedePharmacieetd’Odonto-Stomalogie,Bamako,Mali,9HelenKellerInternational,RegionalOfficeforAfrica,Dakar, Senegal Abstract Background:Preventivechemotherapyagainstschistosomiasishasbeenimplementedsince2005inMali,targetingschool- agechildrenandadultsathighrisk.Across-sectionalsurveywasconductedin2010toevaluatetheimpactofrepeated treatmentamongschool-agechildreninthehighly-endemicregionofSegou. Methodology/PrincipalFindings:Thesurveywasconductedinsixsentinelschoolsinthreehighly-endemicdistricts,and 640 school children aged 7–14 years were examined. Infections with Schistosoma haematobium and S. mansoni were diagnosedwiththeurinefiltrationandtheKato-Katzmethodrespectively.OverallprevalenceofS.haematobiuminfection was 61.7%, a significant reduction of 30% from the baseline in 2004 (p,0.01), while overall prevalence of S. mansoni infectionwas12.7%whichwasnotsignificantlydifferentfromthebaseline.OverallmeanintensityofS.haematobiumandS. mansoniinfectionwas180.4eggs/10mlofurineand88.2epgin2004respectively.Thesewerereducedto33.2eggs/10ml ofurineand43.2epgin2010respectively,asignificantreductionof81.6%and51%(p,0.001).TheproportionofheavyS. haematobiuminfectionswasreducedfrom