Silent but Not Static Accelerated Base-Pair Substitution in Silenced Chromatin of Budding Yeasts 英文参考文献.docVIP

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Silent but Not Static Accelerated Base-Pair Substitution in Silenced Chromatin of Budding Yeasts 英文参考文献.doc

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Silent but Not Static Accelerated Base-Pair Substitution in Silenced Chromatin of Budding Yeasts 英文参考文献

SilentbutNotStatic:AcceleratedBase-PairSubstitution inSilencedChromatinofBuddingYeasts LeonidTeytelman1,MichaelB.Eisen1,2,3,JasperRine1,2 * 1DepartmentofMolecularCellBiology,UniversityofCaliforniaBerkeley,Berkeley,California,UnitedStatesofAmerica,2CaliforniaInstituteforQuantitativeBiosciences, Berkeley,California,UnitedStatesofAmerica,3CenterforIntegrativeGenomics,UniversityofCaliforniaBerkeley,Berkeley,California,UnitedStatesofAmerica Abstract Subtelomeric DNA in budding yeasts, like metazoan heterochromatin, is gene poor, repetitive, transiently silenced, and highlydynamic.Therapidevolutionofsubtelomericregionsiscommonlythoughttoarisefromtransposonactivityand increased recombination between repetitive elements. However, we found evidence of an additional factor in this diversification.Weobservedasurprisinglevelofnucleotidedivergenceintranscriptionallysilencedregionsininter-species comparisons of Saccharomyces yeasts. Likewise, intra-species analysis of polymorphisms also revealed increased SNP frequencies in both intergenic and synonymous coding positions of silenced DNA. This analysis suggested that silenced DNAinSaccharomycescerevisiaeandcloselyrelatedspecieshadincreasedsinglebase-pairsubstitutionthatwaslikelydue totheeffectsofthesilencingmachineryonDNAreplicationorrepair. Citation:TeytelmanL,EisenMB,RineJ(2008)SilentbutNotStatic:AcceleratedBase-PairSubstitutioninSilencedChromatinofBuddingYeasts.PLoSGenet4(11): e1000247.doi:10.1371/journal.pgen.1000247 Editor:GregoryS.Barsh,StanfordUniversitySchoolofMedicine,UnitedStatesofAmerica ReceivedMarch31,2008;AcceptedOctober1,2008;PublishedNovember7,2008 Copyright: ?2008 Teytelman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNationalInstitutesofHealthgrantsGM31105toJRandR01-HG002779toMBE,andbyanNSFpredoctoralf