Simultaneous EEG-fMRI during a Working Memory Task Modulations in Low and High Frequency Bands 英文参考文献.docVIP

SimultaneousEEG-fMRIduringaWorkingMemoryTask: ModulationsinLowandHighFrequencyBands LarsMichels1*.,KerstinBucher2.,RafaelLu¨chinger3,PeterKlaver2,4,ErnstMartin2,4 ,Daniel Jeanmonod1,4,DanielBrandeis3,4,5 1Functional Neurosurgery, University HospitalZu¨rich, Zu¨rich, Switzerland, 2MR-Center, University Children’sHospital, Zu¨rich, Switzerland, 3Department of Child and AdolescentPsychiatry,UniversityofZu¨rich,Zu¨rich,Switzerland,4Zu¨richCenterforIntegrativeHumanPhysiology(ZIHP),Zu¨rich,Switzerland,5DepartmentofChildand AdolescentPsychiatryandPsychotherapy,CentralInstituteofMentalHealth,Mannheim,Germany Abstract Background:EEGstudiesofworkingmemory(WM)havedemonstratedloaddependentfrequencybandmodulations.FMRI studies have localized load modulated activity to the dorsolateral prefrontal cortex (DLPFC), medial prefrontal cortex (MPFC),andposteriorparietalcortex(PPC).Recently,anEEG-fMRIstudyfoundthatlowfrequencyband(thetaandalpha) activity negatively correlated with the BOLD signal during the retention phase of a WM task. However, the coupling of higher(betaandgamma)frequencieswiththeBOLDsignalduringWMisunknown. Methodology:In16healthyadultsubjects,wefirstinvestigatedEEG-BOLDsignalcorrelationsfortheta(5–7Hz),alpha1(8– 10),alpha2(10–12Hz),beta1(13–20),beta2(20–30Hz),andgamma(30–40Hz)duringtheretentionperiodofaWMtask withsetsize2and5.Secondly,weinvestigatedwhetherloadsensitivebrainregionsarecharacterisedbyeffectsthatrelate frequencybandstoBOLDsignalseffects. Principal Findings: We found negative theta-BOLD signal correlations in the MPFC, PPC, and cingulate cortex (ACC and PCC).Foralpha1positivecorrelationswiththeBOLDsignalwerefoundinACC,MPFC,andPCC;negativecorrelationswere observedinDLPFC,PPC,andinferiorfrontalgyrus(IFG).Negativealpha2-BOLDsignalcorrelationswereobservedinparieto- occipital regions. Beta1-BOLD signal correlations were positive in ACC and negative in precentral and superior temporal gyrus. Beta2 and gamma showed only positive correlations with BOLD, e.g.,