So what have data standards ever done for us The view from metabolomics 英文参考文献.docVIP

Gri?n and Steinbeck Genome Medicine 2010,2:38 /content/2/6/38 MUSINGS So what have data standards ever done for us? The view from metabolomics 1,2,3 4 Julian L Grin* and Christoph Steinbeck reporting microarray data (the Minimum Information About a Microarray Experiment or MIAME) and, in conjunction with the European Bioinformatics Institute (EBI) and the National Institutes of Health (NIH), the Abstract The standardization of reporting of data promises to revolutionize biology by allowing community access to data generated in laboratories across the globe. This approach has already inuenced genomics and transcriptomics. Projects that have previously been viewed as being too big to implement can now be distributed across multiple sites. There are now public databases for gene sequences, transcriptomic proling and proteomic experiments. However, progress in the metabolomic community has seemed to falter recently, and whereas there are ontologies to describe the metadata for metabolomics there are still no central repositories for the datasets themselves. Here, we examine some of the challenges and potential benets of further eorts towards data standardization in metabolomics and metabonomics. community developed databases to house the experimental data generated by microarray experiments, such as e ArrayExpress Archive and the Gene Expres- sion Omnibus [1,2]. It was no accident that these developments occurred in parallel, because there is ?rst a need to de?ne a standard reporting language (ontology) before the creation of a database. As well as the ‘carrot’ of a community-wide resource, the MGED society was also incredibly successful at getting journals on board to police the deposition of data. e next logical extension for functional genomics after MIAME was to extend these developments from