Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens A Review 英文参考文献.docVIP

Sensors 2009, 9, 5740-5769; doi:10.3390/OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review María-Isabel Rocha-Gaso 1, Carmen March-Iborra 2, ángel Montoya-Baides 2 and Antonio Arnau-Vives 1,* 1 Grupo de Fenómenos Ondulatorios, Departamento de Ingeniería Electrónica, Universidad Politécnica de Valencia, Spain 2 Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano, Universidad Politécnica de Valencia, Spain * Author to whom correspondence should be addressed; E-Mail: aarnau@eln.upv.es; Tel.: +34-963 879 600 Received: 31 May 2009; in revised form: 7 July 2009 / Accepted: 14 July 2009 / Published: 20 July 2009 Abstract: This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices - Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) - have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this wo