trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels 英文参考文献.docVIP

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trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels 英文参考文献.doc

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trans-Caryophyllene,aNaturalSesquiterpene,CausesTrachealSmoothMuscleRelaxationthroughBlockadeofVoltage-DependentCa2Channels英文参考文献

Molecules 2012, 17, 11965-11977; doi:10.3390/molecules171011965 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article trans-Caryophyllene, a Natural Sesquiterpene, Causes Tracheal Smooth Muscle Relaxation through Blockade of Voltage-Dependent Ca2+ Channels Leidiane Pinho-da-Silva 1,2,?, Paula Virgínia Mendes-Maia 1,2,? , Taylena Maria do Nascimento Garcia Teófilo 1, Roseli Barbosa 1, Vania Marilande Ceccatto 1, Andrelina Noronha Coelho-de-Souza 1, Jader Santos Cruz 3,* and José Henrique Leal-Cardoso 1,* 1 Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Paranjana #1700, Fortaleza 60740-000, Ceará, Brazil 2 Programa de Pos-Gradua??o em Fisiologia e Farmacologia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos #6627, ICB-UFMG, Belo Horizonte 31270-010, Minas Gerais, Brazil 3 Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos #6627, ICB-UFMG, Belo Horizonte 31270-010, Minas Gerais, Brazil ? These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: jader.cruz@pq.br (J.S.C.); lealcard@ (J.H.L.-C.); Tel.: +55-31-3409-2668 (J.S.C.); Tel.: +55-85-3101-9814 (J.H.L.-C.); Fax: +55-85-288-8333(J.H.L.-C.). Received: 10 July 2012; in revised form: 19 September 2012 / Accepted: 5 October 2012 / Published: 11 October 2012 Abstract: trans-Caryophyllene is a major component in the essential oils of various species of medicinal plants used in popular medicine in Brazil. It belongs to the chemical class of the sesquiterpenes and has been the subject of a number of studies. Here, we evaluated the effects of this compound in airway smooth muscle. The biological activities of trans-caryophyllene were examined in isolated bath organs to investigate the effect in basal tonus. Electromechanical and pharmacomechanical couplings were evaluated through the respon