Translational bioinformatics in the cloud an affordable alternative 英文参考文献.docVIP

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Translational bioinformatics in the cloud an affordable alternative 英文参考文献.doc

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Translational bioinformatics in the cloud an affordable alternative 英文参考文献

Dudleyetal.GenomeMedicine2010,2:51 /content/2/8/51 CORRESPONDENCE OpenAccess Translationalbioinformaticsinthecloud: anaffordablealternative JoelTDudley1,2,3,YannickPouliot2,3,RongChen2,3,AlexanderAMorgan1,2,3,AtulJButte2,3* Abstract Withthecontinuedexponentialexpansionofpubliclyavailablegenomicdataandaccesstolow-cost,high- throughputmoleculartechnologiesforprofilingpatientpopulations,computationaltechnologiesandinformatics arebecomingvitalconsiderationsingenomicmedicine.Althoughcloudcomputingtechnologyisbeingheralded asakeyenablingtechnologyforthefutureofgenomicresearch,availablecasestudiesarelimitedtoapplications inthedomainofhigh-throughputsequencedataanalysis.Thegoalofthisstudywastoevaluatethecomputa- tionalandeconomiccharacteristicsofcloudcomputinginperformingalarge-scaledataintegrationandanalysis representativeofresearchproblemsingenomicmedicine.Wefindthatthecloud-basedanalysiscomparesfavor- ablyinbothperformanceandcostincomparisontoalocalcomputationalcluster,suggestingthatcloudcomput- ingtechnologiesmightbeaviableresourceforfacilitatinglarge-scaletranslationalresearchingenomicmedicine. Background researchers to ask novel and important translational The intensely data-driven and integrative nature of questions such as, ‘Which genes are most likely to be research in genomic medicine in the post-genomic era up-regulated specifically in cancers compared to all presentssignificantchallengesinformulatingandtesting other human diseases’ [5]? Given that GEO contains important translational hypotheses. Advances in high- hundreds of thousands of clinical microarray samples, throughputexperimentaltechnologiescontinuetodrive each with tens of thousands of gene abundance mea- the exponential growth in publicly available genomic surements,evenastraightforwardanalysisofthesedata data, and the integration and interpretation of these could require many billions or even trillions of immense volumes of data towards direct, measureable improvementsinpatientheal