Two New Constituents from Artemisia capillaris Thunb. 英文参考文献.docVIP

Molecules 2008, 13, 267-271 molecules ISSN 1420-3049 ? 2008 by MDPI /molecules Communication Two New Constituents from Artemisia capillaris Thunb. Hong-Yu Ma 1, Yi Sun 1, Yu-Zhi Zhou 1, Min Hong 2 and Yue-Hu Pei 1,* 1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University; Shenyang 110016, P.R. China 2 National Standard Laboratory for Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, P.R. China * Author to whom correspondence should be addressed; E-mail: peiyueh@; Tel.: +86-24-Received: 26 November 2007; in revised form: 2 February 2008 / Accepted: 4 February 2008 / Published: 5 February 2008 Abstract: Two new compounds, 6′-O-caffeoyl-p-hydroxyacetophenone-4-O-β-D-gluco- pyranoside (1) and 6-amino-9-[1-(3,4-dihydroxyphenyl)ethyl]-9H-purine (2) were isolated from the aerial parts of Artemisia capillaris Thunb. The structures were established on the basis of spectral data. Keywords: Artemisia capillaris; p-hydroxyacetophenone; adenine Introduction Infusions of the buds, stems and leaves of Artemisia capillaris (Yin Chen Hao, Capillary or Oriental Wormwood) have been used in Chinese Traditional Medicine since antiquity as a cholagogic, antipyretic, anti-inflammatory and diuretic purposes and in the treatment of jaundice [1-6]. Coumarins, flavonol glycosides and a group of unidentified aglycones have been reported so far from the inflorescence of Artemisia capillaris [7,8]. Our investigation of the aerial parts of this plant has led to the isolation of two new constituents. This paper deals with the isolation and structural determination of these compounds.  Molecules 2008, 13 268 Results and Discussion Compound 1, a yellow powder, was formulated as C23H24O10 on the basis of HR-FAB-MS data (m/z 461.1436, [M+H]+, calcd. 461.1446). Its 1H-NMR spectrum indicated one methyl (δ 2.38, s), a 1,4-disubstituted benzene ring [δ 7.85 (2H